LGALS8

Lectin, galactoside-binding, soluble, 8 (galectin 8)
Identifiers
Symbols	LGALS8 ; Gal-8; PCTA-1; PCTA1; Po66-CBP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31386
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO
RNA expression pattern
File:PBB GE LGALS8 208934 s at tn.png
File:PBB GE LGALS8 208935 s at tn.png
File:PBB GE LGALS8 208936 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Lectin, galactoside-binding, soluble, 8 (galectin 8), also known as LGALS8, is a human gene.

This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified.

Further reading

• Bidon N, Brichory F, Bourguet P; et al. (2001). "Galectin-8: a complex sub-family of galectins (Review)". Int. J. Mol. Med. 8 (3): 245–50. PMID 11494049.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Danguy A, Camby I, Kiss R (2002). "Galectins and cancer". Biochim. Biophys. Acta. 1572 (2–3): 285–93. PMID 12223276.CS1 maint: Multiple names: authors list (link)
• Bidon-Wagner N, Le Pennec JP (2004). "Human galectin-8 isoforms and cancer". Glycoconj. J. 19 (7–9): 557–63. doi:10.1023/B:GLYC.0000014086.38343.98. PMID 14758080.
• Hadari YR, Paz K, Dekel R; et al. (1995). "Galectin-8. A new rat lectin, related to galectin-4". J. Biol. Chem. 270 (7): 3447–53. PMID 7852431.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Su ZZ, Lin J, Shen R; et al. (1996). "Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family". Proc. Natl. Acad. Sci. U.S.A. 93 (14): 7252–7. PMID 8692978.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bassen R, Brichory F, Caulet-Maugendre S; et al. (2000). "Expression of Po66-CBP, a type-8 galectin, in different healthy, tumoral and peritumoral tissues". Anticancer Res. 19 (6B): 5429–33. PMID 10697573.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hadari YR, Arbel-Goren R, Levy Y; et al. (2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell. Sci. 113 ( Pt 13): 2385–97. PMID 10852818.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gopalkrishnan RV, Roberts T, Tuli S; et al. (2000). "Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene". Oncogene. 19 (38): 4405–16. doi:10.1038/sj.onc.1203767. PMID 10980616.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bidon N, Brichory F, Hanash S; et al. (2001). "Two messenger RNAs and five isoforms for Po66-CBP, a galectin-8 homolog in a human lung carcinoma cell line". Gene. 274 (1–2): 253–62. PMID 11675018.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagy N, Bronckart Y, Camby I; et al. (2002). "Galectin-8 expression decreases in cancer compared with normal and dysplastic human colon tissue and acts significantly on human colon cancer cell migration as a suppressor". Gut. 50 (3): 392–401. PMID 11839721.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maier C, Rösch K, Herkommer K; et al. (2003). "A candidate gene approach within the susceptibility region PCaP on 1q42.2-43 excludes deleterious mutations of the PCTA-1 gene to be responsible for hereditary prostate cancer". Eur. Urol. 42 (3): 301–7. PMID 12234517.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Levy Y, Ronen D, Bershadsky AD, Zick Y (2003). "Sustained induction of ERK, protein kinase B, and p70 S6 kinase regulates cell spreading and formation of F-actin microspikes upon ligation of integrins by galectin-8, a mammalian lectin". J. Biol. Chem. 278 (16): 14533–42. doi:10.1074/jbc.M207380200. PMID 12569102.CS1 maint: Multiple names: authors list (link)
• Ideo H, Seko A, Ishizuka I, Yamashita K (2004). "The N-terminal carbohydrate recognition domain of galectin-8 recognizes specific glycosphingolipids with high affinity". Glycobiology. 13 (10): 713–23. doi:10.1093/glycob/cwg094. PMID 12851289.CS1 maint: Multiple names: authors list (link)
• Nishi N, Shoji H, Seki M; et al. (2004). "Galectin-8 modulates neutrophil function via interaction with integrin alphaM". Glycobiology. 13 (11): 755–63. doi:10.1093/glycob/cwg102. PMID 12881409.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arbel-Goren R, Levy Y, Ronen D, Zick Y (2005). "Cyclin-dependent kinase inhibitors and JNK act as molecular switches, regulating the choice between growth arrest and apoptosis induced by galectin-8". J. Biol. Chem. 280 (19): 19105–14. doi:10.1074/jbc.M502060200. PMID 15753078.CS1 maint: Multiple names: authors list (link)