LRRTM1 is the first gene linked to increased odds of being left-handed, when inherited from the father's side.[5] Possessing one particular variant of the LRRTM1 gene slightly raises the risk of psychoticmental illnesses such as schizophrenia, again only if inherited from the father's side.[5] As well, LRRTM1 has been associated with measures of schizotypy in non-clinical populations,[6] indicating that the gene may have shared effects on neurodevelopment in both healthy and unhealthy individuals and individuals with schizophrenia.
LRRTM1 is also critically involved in synapse formation within the dorsal Lateral geniculate nucleus (dLGN) of mice. LRRTM1 aids in the assembly of complex retinogenciulate synapses in mice, which are believed to help process complex visual signals. Lack of this gene shows decreased performance in complex visual tasks.[7]
↑Laurén J, Airaksinen MS, Saarma M, Timmusk T (April 2003). "A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system". Genomics. 81 (4): 411–21. doi:10.1016/S0888-7543(03)00030-2. PMID12676565.
↑ 5.05.1Francks C, Maegawa S, Laurén J, Abrahams BS, Velayos-Baeza A, Medland SE, Colella S, Groszer M, McAuley EZ, Caffrey TM, Timmusk T, Pruunsild P, Koppel I, Lind PA, Matsumoto-Itaba N, Nicod J, Xiong L, Joober R, Enard W, Krinsky B, Nanba E, Richardson AJ, Riley BP, Martin NG, Strittmatter SM, Möller HJ, Rujescu D, St Clair D, Muglia P, Roos JL, Fisher SE, Wade-Martins R, Rouleau GA, Stein JF, Karayiorgou M, Geschwind DH, Ragoussis J, Kendler KS, Airaksinen MS, Oshimura M, DeLisi LE, Monaco AP (December 2007). "LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia". Mol. Psychiatry. 12 (12): 1129–39, 1057. doi:10.1038/sj.mp.4002053. PMC2990633. PMID17667961. Lay summary – BBC News.
↑Leach EL, Prefontaine G, Hurd PL, Crespi BJ (Jun 2014). "The imprinted gene LRRTM1 mediates schizotypy and handedness in a nonclinical population". Journal of Human Genetics. 59 (6): 332–336. doi:10.1038/jhg.2014.30. PMID24785688.
↑Van Name, Jonathan; Monavarfeshani, Aboozar; Fox, Michael (July 2017). "The role of complex retinogeniculate synapses in mouse visual behavior".
Further reading
Leach EL, Prefontaine G, Hurd PL, Crespi BJ (Jun 2014). "The imprinted gene LRRTM1 mediates schizotypy and handedness in a nonclinical population". Journal of Human Genetics. 59 (6): 332–336. doi:10.1038/jhg.2014.30. PMID24785688.
Crow TJ, Close JP, Dagnall AM, Priddle TH (2009). "Where and what is the right shift factor or cerebral dominance gene? A critique of Francks et al. (2007)". Laterality. 14 (1): 3–10. doi:10.1080/13576500802574984. PMID19125366.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Ludwig KU, Mattheisen M, Mühleisen TW, Roeske D, Schmäl C, Breuer R, Schulte-Körne G, Müller-Myhsok B, Nöthen MM, Hoffmann P, Rietschel M, Cichon S (August 2009). "Supporting evidence for LRRTM1 imprinting effects in schizophrenia". Mol. Psychiatry. 14 (8): 743–5. doi:10.1038/mp.2009.28. PMID19626025.
McManus C, Nicholls M, Vallortigara G (2009). "Editorial commentary: is LRRTM1 the gene for handedness?". Laterality. 14 (1): 1–2. doi:10.1080/13576500802542577. PMID19125365.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Francks C (2009). "Understanding the genetics of behavioural and psychiatric traits will only be achieved through a realistic assessment of their complexity". Laterality. 14 (1): 11–6. doi:10.1080/13576500802536439. PMID19125367.
