Lapachol
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Lapachol is a natural organic compound isolated from the lapacho tree (Tabebuia avellandedae)[1] Chemically, it is a derivative of naphthoquinone, related to vitamin K.
Once studied as a possible treatment for some types of cancer, lapachol's potential is now considered low due to its toxic side effects.[2][3][4][5]
References
- ↑ Record, Samuel J. Lapachol. Tropical Woods (1925), 1 7-9.
- ↑ Felício AC, Chang CV, Brandão MA, Peters VM, Guerra Mde O (2002). "Fetal growth in rats treated with lapachol". Contraception. 66 (4): 289–93. PMID 12413627.
- ↑ Oral toxicology studies with lapachol. Morrison, Robert K.; Brown, Donald Emerson; Oleson, Jerome J.; Cooney, David A. Toxicology and Applied Pharmacology (1970), 17(1), 1-11.
- ↑ Guerra Mde O, Mazoni AS, Brandão MA, Peters VM (2001). "Toxicology of Lapachol in rats: embryolethality". Brazilian journal of biology = Revista brasleira de biologia. 61 (1): 171–4. PMID 11340475.
- ↑ de Cássia da Silveira E Sá R, de Oliveira Guerra M (2007). "Reproductive toxicity of lapachol in adult male Wistar rats submitted to short-term treatment". Phytotherapy research : PTR. 21 (7): 658–62. doi:10.1002/ptr.2141. PMID 17421057.