Laryngeal cancer epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2], Rim Halaby, M.D. [3], Faizan Sheraz, M.D. [4]
Overview
The prevalence of laryngeal cancer is approximately 19.5 per 100,000 individuals in the United States. The incidence of laryngeal cancer is approximately 3.3 per 100,000 individuals in the United States. The estimated number of new cases in the United States in 2014 is 12,630 which corresponds to 0.8% of all new cancer cases. Laryngeal cancer is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH), which means that laryngeal cancer affects less than 200,000 people in the US population. In the United Kingdom, 2,369 people were diagnosed with laryngeal cancer in 2011.
Epidemiology and Demographics
Prevalence
- The prevalence of laryngeal cancer is approximately 19.5 per 100,000 individuals in the United States.[1][2][3]
Incidence
- The incidence of laryngeal cancer is approximately 3.3 per 100,000 individuals in the United States.[1][2][4]
- In the United Kingdom, 2,369 people were diagnosed with laryngeal cancer in 2011.[5][3]
Age
- While the overall age-adjusted incidence of laryngeal cancer in the United States between 2007 and 2011 is 3.3 per 100,000, the age-adjusted incidence of laryngeal cancer by age category is:[1][4]
- Under 65 years: 1.6 per 100,000
- 65 and over: 1.48 per 100,000
Genetics
Loss of chromosomes 3p, 5q, 8p, 9p, 18q and 21q have been reported in laryngeal cancer[6]
Gender
- In the United States, the age-adjusted prevalence of laryngeal cancer by gender in 2011 was:[1]
- In males: 35.8 per 100,000
- In females: 6.6 per 100,000
- In the United States, the delay-adjusted incidence of laryngeal cancer by gender in 2011 was:[1]
- In males: 5.28 per 100,000 persons
- In females: 1.1 per 100,000 persons
- In the United States, the age-adjusted incidence of laryngeal cancer by gender on 2011 was:[1]
- In males: 5.18 per 100,000 persons
- In females: 1.08 per 100,000 persons
- Shown below is an image depicting the delay-adjusted incidence and observed incidence of laryngeal cancer by gender and race in the United States between 1975 and 2011. These graphs are adapted from SEER: The Surveillance, Epidemiology, and End Results Program of the National Cancer Institute.[1]
Race
- Shown below is a table depicting the age-adjusted prevalence of laryngeal cancer by race in 2011 in the United States.[1][7][8]
| All Races | White | Black | Asian/Pacific Islander | Hispanic | |
| Age-adjusted prevalence | 19.5 per 100,000 | 20.5 per 100,000 | 26.3 per 100,000 | 8.8 per 100,000 | 15 per 100,000 |
- Shown below is an image depicting the incidence of laryngeal cancer by race in the United States between 1975 and 2011.[1]
API: Asian/Pacific Islander; AI/AN: American Indian/ Alaska Native
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.
- ↑ 2.0 2.1 Lambert R, Sauvaget C, de Camargo Cancela M, Sankaranarayanan R (August 2011). "Epidemiology of cancer from the oral cavity and oropharynx". Eur J Gastroenterol Hepatol. 23 (8): 633–41. doi:10.1097/MEG.0b013e3283484795. PMID 21654320.
- ↑ 3.0 3.1 Siegel RL, Miller KD, Jemal A (January 2017). "Cancer Statistics, 2017". CA Cancer J Clin. 67 (1): 7–30. doi:10.3322/caac.21387. PMID 28055103.
- ↑ 4.0 4.1 Bray F, Ren JS, Masuyer E, Ferlay J (March 2013). "Global estimates of cancer prevalence for 27 sites in the adult population in 2008". Int. J. Cancer. 132 (5): 1133–45. doi:10.1002/ijc.27711. PMID 22752881.
- ↑ Cancer research UK
- ↑ de Miguel-Luken MJ, Chaves-Conde M, Carnero A (May 2016). "A genetic view of laryngeal cancer heterogeneity". Cell Cycle. 15 (9): 1202–12. doi:10.1080/15384101.2016.1156275. PMID 26940775.
- ↑ Settle K, Posner MR, Schumaker LM, Tan M, Suntharalingam M, Goloubeva O, Strome SE, Haddad RI, Patel SS, Cambell EV, Sarlis N, Lorch J, Cullen KJ (September 2009). "Racial survival disparity in head and neck cancer results from low prevalence of human papillomavirus infection in black oropharyngeal cancer patients". Cancer Prev Res (Phila). 2 (9): 776–81. doi:10.1158/1940-6207.CAPR-09-0149. PMC 4459126. PMID 19641042.
- ↑ DeSantis C, Naishadham D, Jemal A (May 2013). "Cancer statistics for African Americans, 2013". CA Cancer J Clin. 63 (3): 151–66. doi:10.3322/caac.21173. PMID 23386565.