Liver transplantation historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]

Liver trasnsplantation Microchapters

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Patient Information

Overview

Historical Perspective

Indications

Pre-surgical management

Choice of donor

Epidemiology and Demographics

Techniques

Complications

Acute rejection

Immune therapy

Post-surgical infection

Prognosis

Overview

In 1952, Vittorio Staudacher was the first to perform a liver transplantation (LT) in a canine species. In 1968, Roy Calne and Roger Williams reported 5 cases of liver transplant, discussing the technical problems by details. In 1984, Bismuth reported the first left-lobe LT in a child. Now, there are hundreds of liver transplant centres in over 80 countries.

Liver transplantation historical perspective

  • In 1952, Vittorio Staudacher was the first to perform a liver transplantation (LT) in a canine species.[1]
  • Thomas Starzl published the first three attempts at human LT. In 1967 the procedure resulted in the first extended survival.[2]
  • In 1968, Roy Calne and Roger Williams reported 5 cases of liver transplant, discussing the technical problems by details.[3]
  • In the late 1970s, the introduction of cyclosporine as part of the immunosuppressive regimen in organ transplantation permitted prevention of rejection and severe opportunistic infections when compared to azathioprine.[4]
  • In 1984, Bismuth reported the first left-lobe LT in a child.
  • In 1988, Pichlmayr performed the first split-LT in Germany.
  • In 1985, Silvano Raia described the first attempt at a living donor graft in a child.[5]
  • Since the nineties, there are hundreds of liver transplant centres in over 80 countries.

References

  1. Busuttil RW, De Carlis LG, Mihaylov PV, Gridelli B, Fassati LR, Starzl TE (2012). "The first report of orthotopic liver transplantation in the Western world". Am J Transplant. 12 (6): 1385–7. doi:10.1111/j.1600-6143.2012.04026.x. PMID 22458426.
  2. STARZL TE, MARCHIORO TL, VONKAULLA KN, HERMANN G, BRITTAIN RS, WADDELL WR (1963). "HOMOTRANSPLANTATION OF THE LIVER IN HUMANS". Surg Gynecol Obstet. 117: 659–76. PMC 2634660. PMID 14100514.
  3. Zarrinpar A, Busuttil RW (2013). "Liver transplantation: past, present and future". Nat Rev Gastroenterol Hepatol. 10 (7): 434–40. doi:10.1038/nrgastro.2013.88. PMID 23752825.
  4. Calne RY, Rolles K, White DJ, Thiru S, Evans DB, McMaster P; et al. (1979). "Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers". Lancet. 2 (8151): 1033–6. PMID 91781.
  5. Strong RW, Lynch SV, Ong TH, Matsunami H, Koido Y, Balderson GA (1990). "Successful liver transplantation from a living donor to her son". N Engl J Med. 322 (21): 1505–7. doi:10.1056/NEJM199005243222106. PMID 2336076.

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