Lymphadenopathy laboratory tests

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]

Laboratory Findings

• Complete blood count and differential count - elevated white cell count is seen in infections, lymphomas, leukemias
• Peripheral smear - to examine parasitic diseases (e.g filariasis, kala-azar)
• Erythrocyte sedimentation rate (ESR) - elevated in infections
• Liver function tests - for hepatitis virus infection
• Urine analysis - for diagnosing systemic infections causing lymphadenopathy
• Lactate dehydrogenase - elevated in lymphomas, leukemias and other malignancies
• Serum uric acid - elevated in lymphomas, leukemias and other malignancies
• Blood cultures - gold standard for diagnosing infections
• Immunoglobulin titers - for hepatitis B
• Heterophile test - for Infectious mononucleosis
• Rapid plasma reagen (RPR) - for Syphilis
• HIV antibody test