Lymphangiomyomatosis medical therapy
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Overview
Medical Therapy
The association of LAM with women of childbearing age suggests that hormonal stimulation plays a role in the disease process, and several approaches to treatment involve diminishing the effect of estrogen. At one time or another, therapeutic approaches have included
- progesterone
- oophorectomy
- tamoxifen
- gonadotropin-releasing hormone (GnRH) agonists
- androgen therapy
No therapy is clearly efficacious, and all have undesirable side-effects. There is some evidence which shows that tamoxifen may actually cause worsening of LAM in some patients.[1][2]
References
- ↑ Clemm C, Jehn U, Wolf-Hornung B, Siemon G, and Walter G (1987). "Lymphangiomyomatosis: a report of three cases treated with tamoxifen". Klin Wochenschr. 65: 391–393.
- ↑ Yu J, Astrinidis A, Howard S, and Henske E (2004). "Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways". Am J Physiol Lung Cell Mol Physiol. 286: L694–L700.