Lymphocytopenia causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.

Overview

Common causes of lymphocytopenia include side effects of drugs that cause platelet changes. Additional common causes include congenital and acquired hematological conditions.

Causes

Common Causes

• Aclarubicin
• Adenosine deaminase deficiency
• Alefacept
• Alemtuzumab
• Antithymocyte globulin
• Aplastic anemia
• Bendamustine
• Blinatumomab
• Cabozantinib
• Chemotherapy
• Chloramphenicol
• Cladribine
• Common variable hypogammaglobulinaemia
• Corticosteroids
• De vaal syndrome
• Dinutuximab
• Doxorubicin
• Elotuzumab
• Eribulin
• Everolimus
• Exemestane
• Fludarabine
• Hodgkin's disease
• Human granulocytic ehrlichiosis
• Human monocytotropic ehrlichiosis
• Idarubicin
• Idelalisib
• Interferon beta
• Ixabepilone
• Legionella pneumophila
• Legionella pneumophila
• Leukemia
• Linezolid
• Lorcaserin
• Lymphangiectasis
• Olaparib
• Olsalazine
• Omacetaxine mepesuccinate
• Oxaliplatin
• Pamidronate
• Pancytopenia
• Pazopanib
• Pentostatin
• Rituximab
• Saxagliptin
• Schimke immunoosseous dysplasia
• Sorafenib
• Sunitinib malate
• Temsirolimus
• Vinblastine
• Waldmann disease
• Wiskott-aldrich syndrome

Causes by Organ System

Cardiovascular	No underlying causes
Chemical/Poisoning	Dimethyl fumarate
Dental	No underlying causes
Dermatologic	Aplasia cutis congenital, Cartilage hair hypoplasia
Drug Side Effect	Aclarubicin, Alefacept, Alemtuzumab, Bendamustine, Blinatumomab, Cabozantinib, Chemotherapy, Chloramphenicol, Cladribine, Corticosteroids, Dinutuximab, Doxorubicin, Elotuzumab, Eribulin, Everolimus, Exemestane, Fludarabine, Idarubicin, Idelalisib, Ixabepilone, Legionella pneumophila, Linezolid, Lorcaserin, Olaparib, Olsalazine, Omacetaxine mepesuccinate, Oxaliplatin, Pamidronate, Pazopanib, Pentostatin, Rituximab, Saxagliptin, Sorafenib, Sunitinib malate, Temsirolimus, Vinblastine
Ear Nose Throat	No underlying causes
Endocrine	No underlying causes
Environmental	No underlying causes
Gastroenterologic	Intestinal lymphangiectasis
Genetic	Mckusick type metaphyseal chondrodysplasia, Purine nucleoside phosphorylase (pnp) deficiency
Hematologic	Adenosine deaminase deficiency, Antithymocyte globulin, Aplastic anemia, Common variable hypogammaglobulinaemia, De vaal syndrome, Hodgkin's disease, Human granulocytic ehrlichiosis, Human monocytotropic ehrlichiosis, Interferon beta, Legionella pneumophila, Leukemia, Lymphangiectasis, Pancytopenia, Schimke immunoosseous dysplasia, Waldmann disease, Wiskott-aldrich syndrome
Iatrogenic	Chemotherapy, Radiation therapy
Infectious Disease	Acute viral nasopharyngitis, Aids, Epstein-barr virus, chronic, Hiv-1 disease, Human granulocytic ehrlichiosis, Human monocytotropic ehrlichiosis, Influenza, Tuberculosis, Typhoid fever, Viral hepatitis
Musculoskeletal/Orthopedic	Myelodysplastic syndrome
Neurologic	Ataxia telangiectasia
Nutritional/Metabolic	Malnutrition
Obstetric/Gynecologic	No underlying causes
Oncologic	Leukemia, Myelodysplastic syndrome
Ophthalmologic	Reticular dysgenesis
Overdose/Toxicity	No underlying causes
Psychiatric	Stress
Pulmonary	Sarcoidosis, Severe acute respiratory syndrome, Tuberculosis, Typhoid fever,
Renal/Electrolyte	Spondyloepiphyseal dysplasia -- nephrotic syndrome
Rheumatology/Immunology/Allergy	Nezelof syndrome, Sarcoidosis, Systemic lupus erythematosus, Wiskott-aldrich syndrome
Sexual	Aids, Hiv-1 disease, Viral hepatitis
Trauma	Excessive physical exercise, Stress
Urologic	No underlying causes
Miscellaneous	No underlying causes

Causes in Alphabetical Order

• Aclarubicin
• Acute viral nasopharyngitis
• Adenosine deaminase deficiency
• Aids
• Alefacept
• Alemtuzumab
• Antithymocyte globulin
• Aplasia cutis congenital
• Aplastic anemia
• Ataxia telangiectasia
• Bendamustine
• Blinatumomab
• Cabozantinib
• Cartilage hair hypoplasia
• Chemotherapy
• Chloramphenicol
• Cladribine
• Common variable hypogammaglobulinaemia
• Corticosteroids
• De vaal syndrome
• Dimethyl fumarate
• Dinutuximab
• Doxorubicin
• Elotuzumab
• Epstein-barr virus
• Eribulin
• Everolimus
• Excessive physical exercise
• Exemestane
• Fludarabine
• Hiv-1 disease
• Hodgkin's disease
• Human granulocytic ehrlichiosis
• Human monocytotropic ehrlichiosis
• Idarubicin
• Idelalisib
• Influenza
• Interferon beta
• Intestinal lymphangiectasis
• Ixabepilone
• Legionella pneumophila
• Leukemia
• Linezolid
• Lorcaserin
• Lymphangiectasis
• Malnutrition
• Mckusick type metaphyseal chondrodysplasia
• Myelodysplastic syndrome
• Nezelof syndrome
• Olaparib
• Olsalazine
• Omacetaxine mepesuccinate
• Oxaliplatin
• Pamidronate
• Pancytopenia
• Pazopanib
• Pentostatin
• Purine nucleoside phosphorylase (pnp) deficiency
• Radiation therapy
• Reticular dysgenesis
• Rituximab
• Sarcoidosis
• Saxagliptin
• Schimke immunoosseous dysplasia
• Severe acute respiratory syndrome
• Sorafenib
• Spondyloepiphyseal dysplasia
• Stress
• Sunitinib malate
• Systemic lupus erythematosus
• Temsirolimus
• Thrombin human
• Tuberculosis
• Typhoid fever
• Vinblastine
• Viral hepatitis
• Waldmann disease
• Wiskott-aldrich syndrome