ME1

Malic enzyme 1, NADP(+)-dependent, cytosolic
File:PBB Protein ME1 image.jpg PDB rendering based on 2aw5.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2aw5​
Identifiers
Symbols	ME1 ; HUMNDME; MES
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20540
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE ME1 204059 s at tn.png
File:PBB GE ME1 204058 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Malic enzyme 1, NADP(+)-dependent, cytosolic, also known as ME1, is a human gene.

This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet.

Further reading

• Povey S, Wilson DE, Harris H; et al. (1978). "Sub-unit structure of soluble and mitochondrial malic enzyme: demonstration of human mitochondrial enzyme in human-mouse hybrids". Ann. Hum. Genet. 39 (2): 203–12. PMID 1088824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tessarolo D, Liguori M, Giacanelli M (1991). "Human malic enzymes in heart and muscle: evidence of a selective distribution". Biochem. Med. Metab. Biol. 45 (1): 1–5. PMID 2015102.CS1 maint: Multiple names: authors list (link)
• Taroni F, Di Donato S (1988). "Purification and properties of cytosolic malic enzyme from human skeletal muscle". Int. J. Biochem. 20 (8): 857–66. PMID 3169368.
• Chen TR, McMorris FA, Creagan R; et al. (1973). "Assignment of the genes for malate oxidoreductase decarboxylating to chromosome 6 and peptidase B and lactate dehydrogenase B to chromosome 12 in man". Am. J. Hum. Genet. 25 (2): 200–7. PMID 4689040.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bukato G, Kochan Z, Swierczyński J (1996). "Different regulatory properties of the cytosolic and mitochondrial forms of malic enzyme isolated from human brain". Int. J. Biochem. Cell Biol. 27 (10): 1003–8. PMID 7496989.CS1 maint: Multiple names: authors list (link)
• González-Manchón C, Ferrer M, Ayuso MS, Parrilla R (1995). "Cloning, sequencing and functional expression of a cDNA encoding a NADP-dependent malic enzyme from human liver". Gene. 159 (2): 255–60. PMID 7622060.CS1 maint: Multiple names: authors list (link)
• Bukato G, Kochan Z, Swierczyński J (1995). "Purification and properties of cytosolic and mitochondrial malic enzyme isolated from human brain". Int. J. Biochem. Cell Biol. 27 (1): 47–54. PMID 7757881.CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Loeber G, Dworkin MB, Infante A, Ahorn H (1994). "Characterization of cytosolic malic enzyme in human tumor cells". FEBS Lett. 344 (2–3): 181–6. PMID 8187880.CS1 maint: Multiple names: authors list (link)
• Chou WY, Huang SM, Chang GG (1996). "Nonidentity of the cDNA sequence of human breast cancer cell malic enzyme to that from the normal human cell". J. Protein Chem. 15 (3): 273–9. PMID 8804575.CS1 maint: Multiple names: authors list (link)
• González-Manchón C, Butta N, Ferrer M; et al. (1997). "Molecular cloning and functional characterization of the human cytosolic malic enzyme promoter: thyroid hormone responsiveness". DNA Cell Biol. 16 (5): 533–44. PMID 9174159.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sylvius N, Tesson F, Gayet C; et al. (2001). "A new locus for autosomal dominant dilated cardiomyopathy identified on chromosome 6q12-q16". Am. J. Hum. Genet. 68 (1): 241–6. PMID 11085912.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Butta N, González-Manchón C, Arias-Salgado EG; et al. (2001). "Cloning and functional characterization of the 5' flanking region of the human mitochondrial malic enzyme gene. Regulatory role of Sp1 and AP-2". Eur. J. Biochem. 268 (10): 3017–27. PMID 11358520.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang Z, Lanks CW, Tong L (2002). "Molecular mechanism for the regulation of human mitochondrial NAD(P)+-dependent malic enzyme by ATP and fumarate". Structure. 10 (7): 951–60. PMID 12121650.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hsieh JY, Liu GY, Chang GG, Hung HC (2006). "Determinants of the dual cofactor specificity and substrate cooperativity of the human mitochondrial NAD(P)+-dependent malic enzyme: functional roles of glutamine 362". J. Biol. Chem. 281 (32): 23237–45. doi:10.1074/jbc.M603451200. PMID 16757477.CS1 maint: Multiple names: authors list (link)