ME2

Malic enzyme 2, NAD(+)-dependent, mitochondrial
File:PBB Protein ME2 image.jpg PDB rendering based on 1do8.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1do8​, 1efk​, 1efl​, 1gz3​, 1gz4​, 1pj2​, 1pj3​, 1pj4​, 1pjl​, 1qr6​
Identifiers
Symbols	ME2 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37615
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE ME2 209397 at tn.png
File:PBB GE ME2 210153 s at tn.png
File:PBB GE ME2 210154 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Malic enzyme 2, NAD(+)-dependent, mitochondrial, also known as ME2, is a human gene.

This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene.

Further reading

• Siebert G, Ritter H, Kömpf J (1980). "Mitochondrial malic enzyme (E.C.1.1.1.40) in human leukocytes: formal genetics and population genetics". Hum. Genet. 51 (3): 319–22. PMID 511162.CS1 maint: Multiple names: authors list (link)
• Saha N, Jeremiah SJ, Povey S (1978). "Further data on mitochondrial malic enzyme in man". Hum. Hered. 28 (6): 421–5. PMID 680703.CS1 maint: Multiple names: authors list (link)
• Loeber G, Infante AA, Maurer-Fogy I; et al. (1991). "Human NAD(+)-dependent mitochondrial malic enzyme. cDNA cloning, primary structure, and expression in Escherichia coli". J. Biol. Chem. 266 (5): 3016–21. PMID 1993674.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taroni F, Gellera C, Di Donato S (1988). "Evidence for two distinct mitochondrial malic enzymes in human skeletal muscle: purification and properties of the NAD(P)+-dependent enzyme". Biochim. Biophys. Acta. 916 (3): 446–54. PMID 3689803.CS1 maint: Multiple names: authors list (link)
• Bukato G, Kochan Z, Swierczyński J (1996). "Different regulatory properties of the cytosolic and mitochondrial forms of malic enzyme isolated from human brain". Int. J. Biochem. Cell Biol. 27 (10): 1003–8. PMID 7496989.CS1 maint: Multiple names: authors list (link)
• Bukato G, Kochan Z, Swierczyński J (1995). "Purification and properties of cytosolic and mitochondrial malic enzyme isolated from human brain". Int. J. Biochem. Cell Biol. 27 (1): 47–54. PMID 7757881.CS1 maint: Multiple names: authors list (link)
• Xu Y, Bhargava G, Wu H; et al. "Crystal structure of human mitochondrial NAD(P)(+)-dependent malic enzyme: a new class of oxidative decarboxylases". 7 (8): 877–889. PMID 10467136.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu Y, Bhargava G, Wu H; et al. (1999). "Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme: a new class of oxidative decarboxylases". Structure. 7 (8): R877–89. PMID 10477256.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang Z, Floyd DL, Loeber G, Tong L (2000). "Structure of a closed form of human malic enzyme and implications for catalytic mechanism". Nat. Struct. Biol. 7 (3): 251–7. doi:10.1038/73378. PMID 10700286.CS1 maint: Multiple names: authors list (link)
• Yang Z, Batra R, Floyd DL; et al. (2000). "Potent and competitive inhibition of malic enzymes by lanthanide ions". Biochem. Biophys. Res. Commun. 274 (2): 440–4. doi:10.1006/bbrc.2000.3163. PMID 10913357.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Butta N, González-Manchón C, Arias-Salgado EG; et al. (2001). "Cloning and functional characterization of the 5' flanking region of the human mitochondrial malic enzyme gene. Regulatory role of Sp1 and AP-2". Eur. J. Biochem. 268 (10): 3017–27. PMID 11358520.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yanaihara N, Kohno T, Takakura S; et al. (2001). "Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus". Genomics. 72 (2): 169–79. doi:10.1006/geno.2000.6454. PMID 11401430.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang Z, Lanks CW, Tong L (2002). "Molecular mechanism for the regulation of human mitochondrial NAD(P)+-dependent malic enzyme by ATP and fumarate". Structure. 10 (7): 951–60. PMID 12121650.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tao X, Yang Z, Tong L (2004). "Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism". Structure. 11 (9): 1141–50. PMID 12962632.CS1 maint: Multiple names: authors list (link)
• Navarro-Lérida I, Martínez Moreno M, Roncal F; et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics. 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Greenberg DA, Cayanis E, Strug L; et al. (2005). "Malic enzyme 2 may underlie susceptibility to adolescent-onset idiopathic generalized epilepsy". Am. J. Hum. Genet. 76 (1): 139–46. doi:10.1086/426735. PMID 15532013.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hung HC, Chien YC, Hsieh JY; et al. (2005). "Functional roles of ATP-binding residues in the catalytic site of human mitochondrial NAD(P)+-dependent malic enzyme". Biochemistry. 44 (38): 12737–45. doi:10.1021/bi050510b. PMID 16171388.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)