MicroRNA 494 is a microRNA that in humans is encoded by the MIR494 gene.[1]
Function
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. This RefSeq represents the predicted microRNA stem-loop.[1]
Kim WK, Park M, Kim YK, Tae YK, Yang HK, Lee JM, Kim H (December 2011). "MicroRNA-494 downregulates KIT and inhibits gastrointestinal stromal tumor cell proliferation". Clinical Cancer Research. 17 (24): 7584–94. doi:10.1158/1078-0432.CCR-11-0166. PMID22042971.
Ohdaira H, Sekiguchi M, Miyata K, Yoshida K (February 2012). "MicroRNA-494 suppresses cell proliferation and induces senescence in A549 lung cancer cells". Cell Proliferation. 45 (1): 32–8. doi:10.1111/j.1365-2184.2011.00798.x. PMID22151897.
