2-Acylglycerol O-acyltransferase 2 also known as acyl-CoA:monoacylglycerol acyltransferase 2 (MGAT2) or Diacylglycerol O-acyltransferase candidate 5 (DC5) is an enzyme that in humans is encoded by the MOGAT2gene.
MOGAT2 and the related MOGAT3 genes are members of the acylglycerol o-acyltransferase family (DGAT2/MOGAT) and are involved in the synthesis of diacylglycerol (DAG) and triacylglycerol (TAG) from monoacylglycerol (MAG).
MOGAT2 and also MOGAT3 are single copy genes in almost all mammals. However, in ruminants both genes have undergone tandem gene expansion, indicate of evolving functionality. MOGAT2 has more than five tandemly duplicated copies in sheep with the first copy expressed in the duodenum and the last copy expressed in the skin, with no expression of any copy detected in the liver.[1][2][3]
References
↑Winter A, van Eckeveld M, Bininda-Emonds OR, Habermann FA, Fries R (Feb 2004). "Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals". Cytogenetic and Genome Research. 102 (1–4): 42–7. doi:10.1159/000075723. PMID14970677.
↑Jiang Y, Xie M, Chen W, Talbot R, Maddox JF, Faraut T, Wu C, Muzny DM, Li Y, Zhang W, Stanton JA, Brauning R, Barris WC, Hourlier T, Aken BL, Searle SM, Adelson DL, Bian C, Cam GR, Chen Y, Cheng S, DeSilva U, Dixen K, Dong Y, Fan G, Franklin IR, Fu S, Fuentes-Utrilla P, Guan R, Highland MA, Holder ME, Huang G, Ingham AB, Jhangiani SN, Kalra D, Kovar CL, Lee SL, Liu W, Liu X, Lu C, Lv T, Mathew T, McWilliam S, Menzies M, Pan S, Robelin D, Servin B, Townley D, Wang W, Wei B, White SN, Yang X, Ye C, Yue Y, Zeng P, Zhou Q, Hansen JB, Kristiansen K, Gibbs RA, Flicek P, Warkup CC, Jones HE, Oddy VH, Nicholas FW, McEwan JC, Kijas JW, Wang J, Worley KC, Archibald AL, Cockett N, Xu X, Wang W, Dalrymple BP (Jun 2014). "The sheep genome illuminates biology of the rumen and lipid metabolism". Science. 344 (6188): 1168–73. doi:10.1126/science.1252806. PMC4157056. PMID24904168.
Further reading
Cao J, Hawkins E, Brozinick J, Liu X, Zhang H, Burn P, Shi Y (Apr 2004). "A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet". The Journal of Biological Chemistry. 279 (18): 18878–86. doi:10.1074/jbc.M313272200. PMID14966132.
Lockwood JF, Cao J, Burn P, Shi Y (Nov 2003). "Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activity". American Journal of Physiology. Endocrinology and Metabolism. 285 (5): E927–37. doi:10.1152/ajpendo.00179.2003. PMID12824082.
Yen CL, Farese RV (May 2003). "MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine". The Journal of Biological Chemistry. 278 (20): 18532–7. doi:10.1074/jbc.M301633200. PMID12621063.
Cao J, Lockwood J, Burn P, Shi Y (Apr 2003). "Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2". The Journal of Biological Chemistry. 278 (16): 13860–6. doi:10.1074/jbc.M300139200. PMID12576479.
