MOPP regimen

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aparna Vuppala, M.B.B.S. [2]

Synonyms and keywords: Mechlorethamine/Prednisone/Procarbazine/Vincristine Regimen; MOPP; MOPP Regimen; MOPP regimen; Mustargen-Oncovin-Procarbazine-Prednisone Regimen; NM/PCB/PRED/VCR

Overview

MOPP regimen refers to a chemotherapy regimen consisting of mechlorethamine, vincristine (Oncovin), procarbazine and prednisone, used alone or in combination with radiation therapy for the treatment of stage I-IV Hodgkin lymphoma. Due to the increased risk of gonadal toxicity, this regimen has been widely replaced by the ABVD regimen.

Regimen

MMechlorethamine

OVincristine (Oncovin)

PProcarbazine

PPrednisone

Indications

• Stage I-IV Hodgkin lymphoma