MRAP2

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Melanocortin 2 receptor accessory protein 2 is a protein that in humans is encoded by the MRAP2 gene.^[1] MRAP2 interacts directly with melanocortin 4 receptor (MCR4).

Knockout of the Mrap2 gene in mice leads to severe obesity. In addition, a rare mutation of the MRAP2 gene in humans leads to severe, early-onset obesity.^[2]

References

↑ "Entrez Gene: Melanocortin 2 receptor accessory protein 2".
↑ Asai M, Ramachandrappa S, Joachim M, Shen Y, Zhang R, Nuthalapati N, Ramanathan V, Strochlic DE, Ferket P, Linhart K, Ho C, Novoselova TV, Garg S, Ridderstrale M, Marcus C, Hirschhorn JN, Keogh JM, O'Rahilly S, Chan LF, Clark AJ, Farooqi IS, Majzoub JA (July 2013). "Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity". Science. 341 (6143): 275–278. doi:10.1126/science.1233000. PMC 3788688. PMID 23869016. Lay summary – The New York Times (2013-07-18).

Sebag JA, Hinkle PM (2010). "Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2". Sci Signal. 3 (116): ra28. doi:10.1126/scisignal.2000593. PMC 2992810. PMID 20371771.
Chan LF, Webb TR, Chung TT, Meimaridou E, Cooray SN, Guasti L, Chapple JP, Egertová M, Elphick MR, Cheetham ME, Metherell LA, Clark AJ (April 2009). "MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family". Proc. Natl. Acad. Sci. U.S.A. 106 (15): 6146–51. doi:10.1073/pnas.0809918106. PMC 2661846. PMID 19329486.
Hofland J, Delhanty PJ, Steenbergen J, Hofland LJ, van Koetsveld PM, van Nederveen FH, de Herder WW, Feelders RA, de Jong FH (May 2012). "Melanocortin 2 receptor-associated protein (MRAP) and MRAP2 in human adrenocortical tissues: regulation of expression and association with ACTH responsiveness". J. Clin. Endocrinol. Metab. 97 (5): E747–54. doi:10.1210/jc.2011-2328. PMID 22419722.
Metherell LA, Chapple JP, Cooray S, David A, Becker C, Rüschendorf F, Naville D, Begeot M, Khoo B, Nürnberg P, Huebner A, Cheetham ME, Clark AJ (February 2005). "Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2". Nat. Genet. 37 (2): 166–70. doi:10.1038/ng1501. PMID 15654338.
Gorrigan RJ, Guasti L, King P, Clark AJ, Chan LF (June 2011). "Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland". J. Mol. Endocrinol. 46 (3): 227–32. doi:10.1530/JME-11-0011. PMC 3111094. PMID 21367968.
Novoselova TV, Jackson D, Campbell DC, Clark AJ, Chan LF (April 2013). "Melanocortin receptor accessory proteins in adrenal gland physiology and beyond". J. Endocrinol. 217 (1): R1–11. doi:10.1530/JOE-12-0501. PMID 23418361.
Sebag JA, Hinkle PM (January 2009). "Regions of melanocortin 2 (MC2) receptor accessory protein necessary for dual topology and MC2 receptor trafficking and signaling". J. Biol. Chem. 284 (1): 610–8. doi:10.1074/jbc.M804413200. PMC 2610514. PMID 18981183.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[entrez-1] "Entrez Gene: Melanocortin 2 receptor accessory protein 2".

[Asai_2013-2] Asai M, Ramachandrappa S, Joachim M, Shen Y, Zhang R, Nuthalapati N, Ramanathan V, Strochlic DE, Ferket P, Linhart K, Ho C, Novoselova TV, Garg S, Ridderstrale M, Marcus C, Hirschhorn JN, Keogh JM, O'Rahilly S, Chan LF, Clark AJ, Farooqi IS, Majzoub JA (July 2013). "Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity". Science. 341 (6143): 275–278. doi:10.1126/science.1233000. PMC 3788688. PMID 23869016. Lay summary – The New York Times (2013-07-18).

[1]

[2]

MRAP2

References

Further reading

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