Macc1, met transcriptional regulator

VALUE_ERROR (nil)
Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

MACC1, MET transcriptional regulator is a protein that in humans is encoded by the MACC1 gene.

Function

MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009].

Further reading

• Kokoszyńska K, Kryński J, Rychlewski L, Wyrwicz LS (2009). "Unexpected domain composition of MACC1 links MET signaling and apoptosis". Acta Biochim. Pol. 56 (2): 317–23. PMID 19499089.
• Stein U, Smith J, Walther W, Arlt F (August 2009). "MACC1 controls Met: what a difference an Sp1 site makes". Cell Cycle. 8 (15): 2467–9. doi:10.4161/cc.8.15.9018. PMID 19556890.
• Stein U, Dahlmann M, Walther W (January 2010). "MACC1 - more than metastasis? Facts and predictions about a novel gene". J. Mol. Med. 88 (1): 11–8. doi:10.1007/s00109-009-0537-1. PMID 19787327.
• Shirahata A, Shinmura K, Kitamura Y, Sakuraba K, Yokomizo K, Goto T, Mizukami H, Saito M, Ishibashi K, Kigawa G, Nemoto H, Hibi K (July 2010). "MACC1 as a marker for advanced colorectal carcinoma". Anticancer Res. 30 (7): 2689–92. PMID 20682999.
• Shirahata A, Sakata M, Kitamura Y, Sakuraba K, Yokomizo K, Goto T, Mizukami H, Saito M, Ishibashi K, Kigawa G, Nemoto H, Hibi K (September 2010). "MACC 1 as a marker for peritoneal-disseminated gastric carcinoma". Anticancer Res. 30 (9): 3441–4. PMID 20944120.
• Shimokawa H, Uramoto H, Onitsuka T, Chundong G, Hanagiri T, Oyama T, Yasumoto K (April 2011). "Overexpression of MACC1 mRNA in lung adenocarcinoma is associated with postoperative recurrence". J. Thorac. Cardiovasc. Surg. 141 (4): 895–8. doi:10.1016/j.jtcvs.2010.09.044. PMID 21093878.
• Galimi F, Torti D, Sassi F, Isella C, Corà D, Gastaldi S, Ribero D, Muratore A, Massucco P, Siatis D, Paraluppi G, Gonella F, Maione F, Pisacane A, David E, Torchio B, Risio M, Salizzoni M, Capussotti L, Perera T, Medico E, Di Renzo MF, Comoglio PM, Trusolino L, Bertotti A (May 2011). "Genetic and expression analysis of MET, MACC1, and HGF in metastatic colorectal cancer: response to met inhibition in patient xenografts and pathologic correlations". Clin. Cancer Res. 17 (10): 3146–56. doi:10.1158/1078-0432.CCR-10-3377. PMID 21447729.
• Shirahata A, Fan W, Sakuraba K, Yokomizo K, Goto T, Mizukami H, Saito M, Ishibashi K, Kigawa G, Nemoto H, Sanada Y, Hibi K (March 2011). "MACC 1 as a marker for vascular invasive hepatocellular carcinoma". Anticancer Res. 31 (3): 777–80. PMID 21498695.
• Chundong G, Uramoto H, Onitsuka T, Shimokawa H, Iwanami T, Nakagawa M, Oyama T, Tanaka F (April 2011). "Molecular diagnosis of MACC1 status in lung adenocarcinoma by immunohistochemical analysis". Anticancer Res. 31 (4): 1141–5. PMID 21508357.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.