Macroamylasemia

Macroamylasemia

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Macroamylasemia is a benign acquired condition, characterized by a serum amylase unusually large in molecular size that has been found to occur in apparently healthy humans as well as in a variety of diseases including liver disease, diabetes, cancer, malabsorption and autoimmune disorders. Most commonly macroamylasemia results from the formation of immune complexes between amylase and immunoglobulins.

Differential diagnosis of causes of macroamylasemia

Macroamylasemia has been associated with:

• Autoimmune disorders
• Cancer
• Celiac disease
• Diabetes
• HIV infection
• Liver disease
• Lymphoma
• Malabsorption
• Monoclonal gammopathy
• Rheumatoid arthritis
• Ulcerative colitis