Major histocompatibility complex class I-related gene protein is a protein that in humans is encoded by the MR1gene.[1][2][3] Human MR1 protein has 341 amino acid residues with a molecular weight of 39 366.[4] The MR1 protein is able to bind to molecules derived from bacterial riboflavinbiosynthesis, and then present it to mucosal associated invariant T cells for activation.[5][6] Within cells, MR1 is mostly stored inside the endoplasmic reticulum, where the binding of bacterial riboflavin-related molecules to MR1 occurs, causing it to be sent to the cell surface for presentation.[7]
References
↑Hashimoto K, Hirai M, Kurosawa Y (August 1995). "A gene outside the human MHC related to classical HLA class I genes". Science. 269 (5224): 693–5. doi:10.1126/science.7624800. PMID7624800.
↑Yamaguchi H, Kurosawa Y, Hashimoto K (September 1998). "Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog". Biochemical and Biophysical Research Communications. 250 (3): 558–64. doi:10.1006/bbrc.1998.9353. PMID9784382.
↑Corbett AJ, Eckle SB, Birkinshaw RW, Liu L, Patel O, Mahony J, Chen Z, Reantragoon R, Meehan B, Cao H, Williamson NA, Strugnell RA, Van Sinderen D, Mak JY, Fairlie DP, Kjer-Nielsen L, Rossjohn J, McCluskey J (May 2014). "T-cell activation by transitory neo-antigens derived from distinct microbial pathways". Nature. 509 (7500): 361–5. doi:10.1038/nature13160. PMID24695216.
↑Kjer-Nielsen L, Patel O, Corbett AJ, Le Nours J, Meehan B, Liu L, Bhati M, Chen Z, Kostenko L, Reantragoon R, Williamson NA, Purcell AW, Dudek NL, McConville MJ, O'Hair RA, Khairallah GN, Godfrey DI, Fairlie DP, Rossjohn J, McCluskey J (November 2012). "MR1 presents microbial vitamin B metabolites to MAIT cells". Nature. 491 (7426): 717–23. doi:10.1038/nature11605. PMID23051753.
↑McWilliam HE, Eckle SB, Theodossis A, Liu L, Chen Z, Wubben JM, Fairlie DP, Strugnell RA, Mintern JD, McCluskey J, Rossjohn J, Villadangos JA (May 2016). "The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1". Nature Immunology. 17 (5): 531–7. doi:10.1038/ni.3416. PMID27043408.
Further reading
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Yamaguchi H, Hirai M, Kurosawa Y, Hashimoto K (September 1997). "A highly conserved major histocompatibility complex class I-related gene in mammals". Biochemical and Biophysical Research Communications. 238 (3): 697–702. doi:10.1006/bbrc.1997.7379. PMID9325151.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Riegert P, Wanner V, Bahram S (October 1998). "Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene". Journal of Immunology. 161 (8): 4066–77. PMID9780177.
Parra-Cuadrado JF, Navarro P, Mirones I, Setién F, Oteo M, Martínez-Naves E (August 2000). "A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene". Tissue Antigens. 56 (2): 170–2. doi:10.1034/j.1399-0039.2000.560211.x. PMID11019920.
Miley MJ, Truscott SM, Yu YY, Gilfillan S, Fremont DH, Hansen TH, Lybarger L (June 2003). "Biochemical features of the MHC-related protein 1 consistent with an immunological function". Journal of Immunology. 170 (12): 6090–8. doi:10.4049/jimmunol.170.12.6090. PMID12794138.
Hempelmann A, Kumar S, Muralitharan S, Sander T (July 2006). "Myofibrillogenesis regulator 1 gene (MR-1) mutation in an Omani family with paroxysmal nonkinesigenic dyskinesia". Neuroscience Letters. 402 (1–2): 118–20. doi:10.1016/j.neulet.2006.03.048. PMID16632198.
