Malignant fibrous histiocytoma pathophysiology

Malignant fibrous histiocytoma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]

Overview

On microscopic histopathological analysis, storiform pattern, nuclear polymorphism, and atypical mitoses are characteristic findings of malignant fibrous histiocytoma.

Microscopic Pathology

On microscopic histopathological analysis, findings of malignant fibrous histiocytoma include:

• Storiform pattern
• Marked nuclear pleomorphism
• Variation is nuclear size, nuclear shape and nuclear staining (especially hyperchromasia)
• Mitoses - abundant; atypical mitoses common
• Necrosis (common)
• Mix of spindle cells and epithelioid cells
• Deep to skin