Mammaglobin-B

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External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
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UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
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Wikidata
View/Edit Human

Mammaglobin-B also known as secretoglobin family 2A member 1 is a protein that in humans is encoded by the SCGB2A1 gene.

SCGB2A1 and breast cancer

SCGB2A1 expression is highly specific of mammary tissue, and has been used for identification and detection of disseminated breast cancer cells.

Further reading

• Molloy MP, Bolis S, Herbert BR, et al. (1998). "Establishment of the human reflex tear two-dimensional polyacrylamide gel electrophoresis reference map: new proteins of potential diagnostic value". Electrophoresis. 18 (15): 2811–5. doi:10.1002/elps.1150181516. PMID 9504814.
• Lehrer RI, Xu G, Abduragimov A, et al. (1998). "Lipophilin, a novel heterodimeric protein of human tears". FEBS Lett. 432 (3): 163–7. doi:10.1016/S0014-5793(98)00852-7. PMID 9720917.
• Zhao C, Nguyen T, Yusifov T, et al. (1999). "Lipophilins: human peptides homologous to rat prostatein". Biochem. Biophys. Res. Commun. 256 (1): 147–55. doi:10.1006/bbrc.1999.0274. PMID 10066439.
• Evans V, Vockler C, Friedlander M, et al. (2001). "Lacryglobin in human tears, a potential marker for cancer". Clin. Experiment. Ophthalmol. 29 (3): 161–3. doi:10.1046/j.1442-9071.2001.00408.x. PMID 11446459.
• Carter D, Douglass JF, Cornellison CD, et al. (2002). "Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer". Biochemistry. 41 (21): 6714–22. doi:10.1021/bi0159884. PMID 12022875.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.
• Sjödin A, Guo D, Sørhaug S, et al. (2003). "Dysregulated secretoglobin expression in human lung cancers". Lung Cancer. 41 (1): 49–56. doi:10.1016/S0169-5002(03)00126-0. PMID 12826312.
• Ouellette RJ, Richard D, Maïcas E (2004). "RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes". Am. J. Clin. Pathol. 121 (5): 637–43. doi:10.1309/MMAC-TXT5-5L8Q-TKC1. PMID 15151203.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Xiao F, Mirwald A, Papaioannou M, et al. (2006). "Secretoglobin 2A1 is under selective androgen control mediated by a peculiar binding site for Sp family transcription factors". Mol. Endocrinol. 19 (12): 2964–78. doi:10.1210/me.2004-0408. PMID 16020486.
• Bernstein JL, Godbold JH, Raptis G, et al. (2005). "Identification of mammaglobin as a novel serum marker for breast cancer". Clin. Cancer Res. 11 (18): 6528–35. doi:10.1158/1078-0432.CCR-05-0415. PMID 16166429.