Mannose receptor C-type 1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Mannose receptor C-type 1 is a protein that in humans is encoded by the MRC1 gene.

Function

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.

Further reading

• DesJardin LE, Kaufman TM, Potts B, Kutzbach B, Yi H, Schlesinger LS (October 2002). "Mycobacterium tuberculosis-infected human macrophages exhibit enhanced cellular adhesion with increased expression of LFA-1 and ICAM-1 and reduced expression and/or function of complement receptors, FcgammaRII and the mannose receptor". Microbiology. 148 (Pt 10): 3161–71. doi:10.1099/00221287-148-10-3161. PMID 12368450.
• Chieppa M, Bianchi G, Doni A, Del Prete A, Sironi M, Laskarin G, Monti P, Piemonti L, Biondi A, Mantovani A, Introna M, Allavena P (November 2003). "Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program". J. Immunol. 171 (9): 4552–60. PMID 14568928.
• Chan TL, Chan YW, Ho JW, Chan C, Chan AS, Chan E, Lam PW, Tse CW, Lee KC, Lau CW, Gwi E, Leung SY, Yuen ST (May 2004). "MSH2 c.1452-1455delAATG is a founder mutation and an important cause of hereditary nonpolyposis colorectal cancer in the southern Chinese population". Am. J. Hum. Genet. 74 (5): 1035–42. doi:10.1086/383591. PMC 1181966. PMID 15042510.
• Zhang J, Zhu J, Imrich A, Cushion M, Kinane TB, Koziel H (June 2004). "Pneumocystis activates human alveolar macrophage NF-kappaB signaling through mannose receptors". Infect. Immun. 72 (6): 3147–60. doi:10.1128/IAI.72.6.3147-3160.2004. PMC 415687. PMID 15155616.
• Napper CE, Taylor ME (October 2004). "The mannose receptor fails to enhance processing and presentation of a glycoprotein antigen in transfected fibroblasts". Glycobiology. 14 (10): 7C–12C. doi:10.1093/glycob/cwh109. PMID 15190005.
• Le Cabec V, Emorine LJ, Toesca I, Cougoule C, Maridonneau-Parini I (June 2005). "The human macrophage mannose receptor is not a professional phagocytic receptor". J. Leukoc. Biol. 77 (6): 934–43. doi:10.1189/jlb.1204705. PMID 15767290.
• Zhang J, Tachado SD, Patel N, Zhu J, Imrich A, Manfruelli P, Cushion M, Kinane TB, Koziel H (September 2005). "Negative regulatory role of mannose receptors on human alveolar macrophage proinflammatory cytokine release in vitro". J. Leukoc. Biol. 78 (3): 665–74. doi:10.1189/jlb.1204699. PMID 16000387.
• Kang PB, Azad AK, Torrelles JB, Kaufman TM, Beharka A, Tibesar E, DesJardin LE, Schlesinger LS (October 2005). "The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis". J. Exp. Med. 202 (7): 987–99. doi:10.1084/jem.20051239. PMC 2213176. PMID 16203868.
• Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A (January 2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.