Mantle cell lymphoma causes

	Mantle cell lymphoma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2] Sowminya Arikapudi, M.B,B.S. [3]

Overview

The causes of mantle cell lymphoma have not been clearly identified.

Mantle cell lymphoma is thought to be caused when the somatic cells acquire non-inherited genetic mutations.
The typical mutation occurring in mantle cell lymphoma due to the “reciprocal translocation” between chromosome 11 and chromosome 14 t(11;14) causes the over expression of cyclin D1 which results in uncontrolled growth of B cells leading to lymphoma development.
However, the initiating factors of these genetic alterations are generally not identifiable. People with no particular risk factors for lymphoma development are commonly affected by these alterations.