Melorheostosis

WikiDoc Resources for Melorheostosis
Articles
Most recent articles on Melorheostosis Most cited articles on Melorheostosis Review articles on Melorheostosis Articles on Melorheostosis in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Melorheostosis Images of Melorheostosis Photos of Melorheostosis Podcasts & MP3s on Melorheostosis Videos on Melorheostosis
Evidence Based Medicine
Cochrane Collaboration on Melorheostosis Bandolier on Melorheostosis TRIP on Melorheostosis
Clinical Trials
Ongoing Trials on Melorheostosis at Clinical Trials.gov Trial results on Melorheostosis Clinical Trials on Melorheostosis at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Melorheostosis NICE Guidance on Melorheostosis NHS PRODIGY Guidance FDA on Melorheostosis CDC on Melorheostosis
Books
Books on Melorheostosis
News
Melorheostosis in the news Be alerted to news on Melorheostosis News trends on Melorheostosis
Commentary
Blogs on Melorheostosis
Definitions
Definitions of Melorheostosis
Patient Resources / Community
Patient resources on Melorheostosis Discussion groups on Melorheostosis Patient Handouts on Melorheostosis Directions to Hospitals Treating Melorheostosis Risk calculators and risk factors for Melorheostosis
Healthcare Provider Resources
Symptoms of Melorheostosis Causes & Risk Factors for Melorheostosis Diagnostic studies for Melorheostosis Treatment of Melorheostosis
Continuing Medical Education (CME)
CME Programs on Melorheostosis
International
Melorheostosis en Espanol Melorheostosis en Francais
Business
Melorheostosis in the Marketplace Patents on Melorheostosis
Experimental / Informatics
List of terms related to Melorheostosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Melorheostosis is usually discovered in childhood, occasionally in adulthood. The male-to-female ratio is usually 1:1. It can occur in a single limb, and the lower extremity is more commonly affected than the upper extremity. The epicenter is periosteal or endosteal. The appearance consists of cortical hyperostosis in one or multiple bones, often with intervening soft-tissue calcification or ossification. The limb involved with melorheostosis often demonstrates joint pain, swelling, and limitation of motion in childhood. There is often associated growth disturbance, muscular contraction, and limb length discrepancy. There may be overlying skin changes. At pathologic analysis, thickened and enlarged osseous trabeculae are noted, associated with fibrous tissue replacement of the marrow space. There is controversy involving the distribution of melorheostosis. It has been suggested that the distribution mimics that of the sclerotomes (zones supplied by individual spinal sensory nerves), implying a neurogenic origin.

Diagnosis

The imaging findings are

• At radiography, contiguous bones of an extremity are often involved, although there may be involvement of a single bone.
• There is cortical hyperostosis with intervening soft-tissue calcification or ossification. Dripping candle wax appearance.
• There may be endosteal hyperostosis with obliteration of the medullary space.

• 
• 
• 

  Dripping candle wax