Meningitis vaccine dosage and administration

Meningitis vaccine
MENVEO® FDA Package Insert
Description
Clinical Pharmacology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Dosage and Administration
How Supplied
Labels and Packages

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]

Dosage And Administration

For intramuscular injection only.

Reconstitution Instructions

MENVEO is supplied in two vials that must be combined prior to administration. MENVEO must be prepared for administration by reconstituting the MenA lyophilized conjugate vaccine component with the MenCYW-135 liquid conjugate vaccine component. Using a graduated syringe, withdraw the entire contents of the vial of MenCYW-135 liquid conjugate component and inject into the MenA lyophilized conjugate component vial. Invert the vial and shake well until the vaccine is dissolved and then withdraw 0.5mL of reconstituted product.

[[File:|800px|thumb]]

Please note that it is normal for a small amount of liquid to remain in the vial following withdrawal of the dose.

Following reconstitution, the vaccine is a clear, colorless solution, free from visible foreign particles. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. If any of these conditions exist, MENVEO should not be administered.

The reconstituted vaccine should be used immediately, but may be held at or below 77°F (25°C) for up to 8 hours.

Administration

Each MENVEO dose should be administered as a single 0.5 mL intramuscular injection, preferably into the anterolateral aspect of the thigh in infants or into the deltoid muscle (upper arm) in toddlers, adolescents and adults. Do not administer MENVEO intravenously, subcutaneously or intradermally.

Dosing Schedule

The dosing schedule for individuals initiating vaccination is as follows:

Infants 2 Months of Age

MENVEO is to be administered as a four-dose series at 2, 4, 6, and 12 months of age.

Children 7 Months through 23 Months of Age

MENVEO is to be administered as a two-dose series with the second dose administered in the second year of life and at least three months after the first dose.

Children 2 Years through 10 Years of Age

MENVEO is to be administered as a single dose. For children 2 years through 5 years of age at continued high risk of meningococcal disease, a second dose may be administered 2 months after the first dose.

Adolescents and Adults 11 Years through 55 Years of Age

MENVEO is to be administered as a single dose.

References

Adapted from the FDA Package Insert.