Mephenesin

Mephenesin

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	M03BX06 (WHO)
Identifiers
IUPAC name 3-(2-methylphenoxy)propane-1,2-diol
CAS Number	59-47-2 N
PubChem CID	4059
ChemSpider	3919 Y
UNII	7B8PIR2954
KEGG	D02595 Y
ChEMBL	ChEMBL229128 Y
NIAID ChemDB	017830
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C10H14O3
Molar mass	182.216 g/mol
3D model (JSmol)	Interactive image
SMILES O(c1ccccc1C)CC(O)CO
InChI InChI=1S/C10H14O3/c1-8-4-2-3-5-10(8)13-7-9(12)6-11/h2-5,9,11-12H,6-7H2,1H3 Y Key:JWDYCNIAQWPBHD-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Mephenesin is a centrally acting muscle relaxant. It can be used as an antidote for strychnine poisoning. Mephenesin however presents with the major drawbacks of having a short duration of action and a much greater effect on the spinal cord than the brain, resulting in pronounced respiratory depression at clinical doses and therefore a very low therapeutic index. It is especially dangerous and potentially fatal in combination with alcohol and other depressants. Mephenesin was used by Dr. Bernard Ludwig and Dr. Frank Milan Berger to synthesize meprobamate, the first tranquilizer to see widespread clinical use. Mephenesin is no longer available in North America but is used in France, Italy and a few other countries. Its use has largely been replaced by the related drug methocarbamol, which is better absorbed

See also

• Chlorphenesin
• Guaifenesin, a structurally-related compound used as an expectorant
• Mephenoxalone
• Methocarbamol