Metaclazepam

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Metaclazepam
File:Metaclazepam.svg
Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC18H18BrClN2O
Molar mass393.705

Metaclazepam (Talis) is a drug which is a benzodiazepine derivative. It is a relatively selective anxiolytic with less sedative or muscle relaxant properties than other benzodiazepines such as diazepam or bromazepam.[1]

Metaclazepam is slightly more effective as an anxiolytic than bromazepam,[2] or diazepam,[3] with a 15mg dose of metaclazepam equivalent to 4mg of bromazepam.[4]



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References

  1. ↑ Buschmann G, Kuhl UG, Rohte O. General pharmacology of the anxiolytic compound metaclazepam in comparison to other benzodiazepines. Arzneimittelforschung. 1985;35(11):1643-55.
  2. ↑ Bilone F, Roncari R. A double-blind comparison of the anxiolytic activity of two benzodiazepines, metaclazepam and bromazepam, in anxiety neurosis. Current Medical Research and Opinion. 1988;11(1):45-7.
  3. ↑ Laakmann G, Blaschke D, Hippius H, Schewe S. Double-blind study of metaclazepam versus diazepam treatment of outpatients with anxiety syndrome. Pharmacopsychiatry. 1989 May;22(3):120-5.
  4. ↑ Marano P, Patti F, Nicoletti F. Controlled study on the anxiolytic activity of a newly-developed benzodiazepine, metaclazepam. Current Medical Research and Opinion. 1988;11(1):41-4.

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