Minimal change disease diagnostic study of choice
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
The diagnostic study of choice for minimal change disease is renal biopsy.
Diagnostic Study of choice
- The diagnostic study of choice for minimal change disease is renal biopsy.[1]
- With four weeks of treatment with steroid therapy, most of the patients with minimal change disease (MCD) will respond positively.
- Before considering renal biopsy steroid therapy can be initiated in patients who fulfill the following criteria because of the invasive process of the biopsy.[2][3]
- Patients must be older than 1 year and less than 12 years.
- Normal complement levels.
- No signs of hypertension, gross hematuria, or a marked increase in serum creatinine.
- By following this protocol in patients with minimal change disease we can avoid unnecessary invasive approach in almost 80% of the patients.[4]
References
- ↑ Vivarelli M, Massella L, Ruggiero B, Emma F (February 2017). "Minimal Change Disease". Clin J Am Soc Nephrol. 12 (2): 332–345. doi:10.2215/CJN.05000516. PMC 5293332. PMID 27940460.
- ↑ "The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the International Study of Kidney Disease in Children". J. Pediatr. 98 (4): 561–4. April 1981. PMID 7205481.
- ↑ Norero C, Delucchi A, Lagos E, Rosati P (May 1996). "[Initial therapy of primary nephrotic syndrome in children: evaluation in a period of 18 months of two prednisone treatment schedules. Chilean Co-operative Group of Study of Nephrotic Syndrome in Children]". Rev Med Chil (in Spanish; Castilian). 124 (5): 567–72. PMID 9035508.
- ↑ "The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the International Study of Kidney Disease in Children". J. Pediatr. 98 (4): 561–4. April 1981. PMID 7205481.