Mumps medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nate Michalak, B.A.
Overview
No antiviral agent currently exists and therefore supportive care is indicated for patients with mumps. Supportive care includes prescribing analgesics, application of warm or cold packs to swollen areas, warm salt water gargles, and fluid intake. Patients should avoid acidic foods or juices. Patients should be isolated for at least 5 days after onset of symptoms.
Medical Therapy
There is no antiviral medication for mumps - mumps is treated with supportive care:[1]
- Analgesics such as acetaminophen for headache or neck pain.
- Aspirin use is discouraged in young children because of studies showing an increased risk of Reye's syndrome.
- Application of intermittent ice or heat to the affected neck area.
- Warm salt water gargles, soft foods, and extra fluids may help relieve symptoms.
- Patients should avoid fruit juice or any acidic foods, since these stimulate the salivary glands, which can be painful.
- Patients should be isolated for at least 5 days after onset of symptoms.
Research Treatments
- A research group published a 1996 report on a chemical extracted from Spirulina platensis, a species of blue-green algae, which inhibited Mumps virus in a viral plaque assay.[2]
- A University of Tokyo group reported in 1992 that research compound TJ13025 ((6'R)-6'-C-methylneplanocin A) had an antiviral effect on four Mumps virus strains cultured in Vero cells.(see 16526604, tables 1 and 2) Additional research improved the synthesis of a particular isomer, RMNPA, of TJ13025 from the racemic product.[3][4]
- A 2005 publication in a Russian journal reports that Myramistin has antiviral activity against Mumps virus in Vero cells culture.[5]
References
- ↑ Gupta, R. K (2005). "Mumps and the UK epidemic 2005". BMJ. 330 (7500): 1132–1135. doi:10.1136/bmj.330.7500.1132. ISSN 0959-8138.
- ↑ Hayashi T, Hayashi K, Maeda M, Kojima I (1996). "Calcium spirulan, an inhibitor of enveloped virus replication, from a blue-green alga Spirulina platensis". J Nat Prod. 59 (1): 83–7. PMID 8984158.
- ↑ Shuto S, Obara T, Yaginuma S, Matsuda A (1997). "New neplanocin analogues. IX. A practical preparation of (6'R)-6'-C-methylneplanocin A (RMNPA), a potent antiviral eileen, and the determination of its 6'-configuration. Diastereoselective deamination by adenosine deaminase". Chem Pharm Bull (Tokyo). 45: 138–42. PMID 9023976. Text " issue1 " ignored (help)
- ↑ Shuto S, Minakawa N, Niizuma S, Kim HS, Wataya Y, Matsuda A (2002). "New neplanocin analogues. 12. Alternative synthesis and antimalarial effect of (6'R)-6'-C-methylneplanocin A, a potent AdoHcy hydrolase inhibitor". J Med Chem. 45 (3): 748–51. PMID 11806727.
- ↑ Agafonov AP, Ignat'ev GM, Svistov VV, Smirnov IV, Krivoshein IuS (2005). "[In vitro study of antiviral activity of Myramistin against measles and mumps viruses]". Antibiot Khimioter. 50 (5–6): 17–9. PMID 16526604.