N6AMT1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

N-6 adenine-specific DNA methyltransferase 1 is a protein that in humans is encoded by the N6AMT1 gene.

Function

The N6AMT1 gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jul 2014].

Further reading

• Figaro S, Scrima N, Buckingham RH, Heurgué-Hamard V (July 2008). "HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1". FEBS Lett. 582 (16): 2352–6. doi:10.1016/j.febslet.2008.05.045. PMID 18539146.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Ren X, Aleshin M, Jo WJ, Dills R, Kalman DA, Vulpe CD, Smith MT, Zhang L (June 2011). "Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity". Environ. Health Perspect. 119 (6): 771–7. doi:10.1289/ehp.1002733. PMC 3114810. PMID 21193388.
• Harari F, Engström K, Concha G, Colque G, Vahter M, Broberg K (July 2013). "N-6-adenine-specific DNA methyltransferase 1 (N6AMT1) polymorphisms and arsenic methylation in Andean women". Environ. Health Perspect. 121 (7): 797–803. doi:10.1289/ehp.1206003. PMC 3702000. PMID 23665909.
• Chen X, Guo X, He P, Nie J, Yan X, Zhu J, Zhang L, Mao G, Wu H, Liu Z, Aga D, Xu P, Smith M, Ren X (January 2017). "Interactive Influence of N6AMT1 and As3MT Genetic Variations on Arsenic Metabolism in the Population of Inner Mongolia, China". Toxicol. Sci. 155 (1): 124–134. doi:10.1093/toxsci/kfw181. PMC 5216648. PMID 27637898.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.