NAIP

NLR family, apoptosis inhibitory protein
Identifiers
Symbols	NAIP ; BIRC1; FLJ42520; NLRB1; psiNAIP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 88706
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

NLR family, apoptosis inhibitory protein, also known as NAIP, is a human gene.

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Further reading

• van der Steege G, Draaijers TG, Grootscholten PM; et al. (1995). "A provisional transcript map of the spinal muscular atrophy (SMA) critical region". Eur. J. Hum. Genet. 3 (2): 87–95. PMID 7552146.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Roy N, Mahadevan MS, McLean M; et al. (1995). "The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy". Cell. 80 (1): 167–78. PMID 7813013.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liston P, Roy N, Tamai K; et al. (1996). "Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes". Nature. 379 (6563): 349–53. doi:10.1038/379349a0. PMID 8552191.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen Q, Baird SD, Mahadevan M; et al. (1998). "Sequence of a 131-kb region of 5q13.1 containing the spinal muscular atrophy candidate genes SMN and NAIP". Genomics. 48 (1): 121–7. doi:10.1006/geno.1997.5141. PMID 9503025.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Monani UR, Lorson CL, Parsons DW; et al. (1999). "A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2". Hum. Mol. Genet. 8 (7): 1177–83. PMID 10369862.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamamoto K, Sakai H, Hadano S; et al. (1999). "Identification of two distinct transcripts for the neuronal apoptosis inhibitory protein gene". Biochem. Biophys. Res. Commun. 264 (3): 998–1006. doi:10.1006/bbrc.1999.1615. PMID 10544044.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mercer EA, Korhonen L, Skoglösa Y; et al. (2000). "NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways". EMBO J. 19 (14): 3597–607. doi:10.1093/emboj/19.14.3597. PMID 10899114.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sanna MG, da Silva Correia J, Ducrey O; et al. (2002). "IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition". Mol. Cell. Biol. 22 (6): 1754–66. PMID 11865055.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Akutsu T, Nishio H, Sumino K; et al. (2002). "Molecular genetics of spinal muscular atrophy: contribution of the NAIP gene to clinical severity". The Kobe journal of medical sciences. 48 (1–2): 25–31. PMID 11912351.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu M, Okada T, Sakai H; et al. (2002). "Functional human NAIP promoter transcription regulatory elements for the NAIP and PsiNAIP genes". Biochim. Biophys. Acta. 1574 (1): 35–50. PMID 11955612.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Notarbartolo M, Cervello M, Dusonchet L, D'Alessandro N (2002). "NAIP-deltaEx10-11: a novel splice variant of the apoptosis inhibitor NAIP differently expressed in drug-sensitive and multidrug-resistant HL60 leukemia cells". Leuk. Res. 26 (9): 857–62. PMID 12127562.CS1 maint: Multiple names: authors list (link)
• Lindholm D, Mercer EA, Yu LY; et al. (2002). "Neuronal apoptosis inhibitory protein: Structural requirements for hippocalcin binding and effects on survival of NGF-dependent sympathetic neurons". Biochim. Biophys. Acta. 1600 (1–2): 138–47. PMID 12445469.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Damiano JS, Oliveira V, Welsh K, Reed JC (2004). "Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses". Biochem. J. 381 (Pt 1): 213–9. doi:10.1042/BJ20031506. PMID 15107016.CS1 maint: Multiple names: authors list (link)
• Davoodi J, Lin L, Kelly J; et al. (2004). "Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9". J. Biol. Chem. 279 (39): 40622–8. doi:10.1074/jbc.M405963200. PMID 15280366.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aubin D, Gagnon A, Grunder L; et al. (2004). "Adipogenic and antiapoptotic protein levels in human adipose stromal cells after weight loss". Obes. Res. 12 (8): 1231–4. PMID 15340105.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schmutz J, Martin J, Terry A; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5". Nature. 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Romanish MT, Lock WM, van de Lagemaat LN; et al. (2007). "Repeated recruitment of LTR retrotransposons as promoters by the anti-apoptotic locus NAIP during mammalian evolution". PLoS Genet. 3 (1): e10. doi:10.1371/journal.pgen.0030010. PMID 17222062.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maier JK, Balabanian S, Coffill CR; et al. (2007). "Distribution of neuronal apoptosis inhibitory protein in human tissues". J. Histochem. Cytochem. 55 (9): 911–23. doi:10.1369/jhc.6A7144.2007. PMID 17510375.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)