Nucleosome assembly protein 1-like 4 is a protein that in humans is encoded by the NAP1L4gene.[1][2]
This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer.[2]
References
↑Hu RJ, Lee MP, Johnson LA, Feinberg AP (Mar 1997). "A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues". Hum Mol Genet. 5 (11): 1743–8. doi:10.1093/hmg/5.11.1743. PMID8923002.
Rodriguez P, Munroe D, Prawitt D, et al. (1997). "Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone". Genomics. 44 (3): 253–65. doi:10.1006/geno.1997.4868. PMID9325046.
Rodriguez P, Pelletier J, Price GB, Zannis-Hadjopoulos M (2000). "NAP-2: histone chaperone function and phosphorylation state through the cell cycle". J. Mol. Biol. 298 (2): 225–38. doi:10.1006/jmbi.2000.3674. PMID10764593.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Rodriguez P, Ruiz MT, Price GB, Zannis-Hadjopoulos M (2005). "NAP-2 is part of multi-protein complexes in HeLa cells". J. Cell. Biochem. 93 (2): 398–408. doi:10.1002/jcb.20163. PMID15368365.