NEIL2

Nei like 2 (E. coli)
Identifiers
Symbols	NEIL2 ; FLJ31644; MGC2832; MGC4505; NEH2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 17032
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Nei like 2 (E. coli), also known as NEIL2, is a human gene.

NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002)[supplied by OMIM]

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hazra TK, Kow YW, Hatahet Z; et al. (2002). "Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions". J. Biol. Chem. 277 (34): 30417–20. doi:10.1074/jbc.C200355200. PMID 12097317.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takao M, Kanno S, Kobayashi K; et al. (2003). "A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue". J. Biol. Chem. 277 (44): 42205–13. doi:10.1074/jbc.M206884200. PMID 12200441.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bandaru V, Sunkara S, Wallace SS, Bond JP (2003). "A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII". DNA Repair (Amst.). 1 (7): 517–29. PMID 12509226.CS1 maint: Multiple names: authors list (link)
• Dou H, Mitra S, Hazra TK (2004). "Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2". J. Biol. Chem. 278 (50): 49679–84. doi:10.1074/jbc.M308658200. PMID 14522990.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Katafuchi A, Nakano T, Masaoka A; et al. (2004). "Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions". J. Biol. Chem. 279 (14): 14464–71. doi:10.1074/jbc.M400393200. PMID 14734554.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bhakat KK, Hazra TK, Mitra S (2004). "Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity". Nucleic Acids Res. 32 (10): 3033–9. doi:10.1093/nar/gkh632. PMID 15175427.CS1 maint: Multiple names: authors list (link)
• Das A, Rajagopalan L, Mathura VS; et al. (2004). "Identification of a zinc finger domain in the human NEIL2 (Nei-like-2) protein". J. Biol. Chem. 279 (45): 47132–8. doi:10.1074/jbc.M406224200. PMID 15339932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Das A, Wiederhold L, Leppard JB; et al. (2007). "NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells". DNA Repair (Amst.). 5 (12): 1439–48. doi:10.1016/j.dnarep.2006.07.003. PMID 16982218.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Broderick P, Bagratuni T, Vijayakrishnan J; et al. (2006). "Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition". BMC Cancer. 6: 243. doi:10.1186/1471-2407-6-243. PMID 17029639.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Katafuchi A, Matsubara M, Terato H; et al. (2007). "Damage specificity of human DNA glycosylases for oxidative pyrimidine lesions". Nucleic Acids Symp Ser (Oxf) (48): 175–6. doi:10.1093/nass/48.1.175. PMID 17150535.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Das S, Chattopadhyay R, Bhakat KK; et al. (2007). "Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress". J. Biol. Chem. 282 (39): 28474–84. doi:10.1074/jbc.M704672200. PMID 17686777.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)