NFKBIZ

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External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
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Wikidata
View/Edit Human

NF-kappa-B inhibitor zeta is a protein that in humans is encoded by the NFKBIZ gene.

This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Kitamura H, Kanehira K, Okita K, Morimatsu M, Saito M (2000). "MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production". FEBS Lett. 485 (1): 53–6. doi:10.1016/S0014-5793(00)02185-2. PMID 11086164.
• Shiina T, Morimatsu M, Kitamura H, Ito T, Kidou S, Matsubara K, Matsuda Y, Saito M, Syuto B (2001). "Genomic organization, chromosomal localization, and promoter analysis of the mouse Mail gene". Immunogenetics. 53 (8): 649–55. doi:10.1007/s00251-001-0376-x. PMID 11797098.
• Haruta H, Kato A, Todokoro K (2001). "Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs". J. Biol. Chem. 276 (16): 12485–8. doi:10.1074/jbc.C100075200. PMID 11278262.
• Yamazaki S, Muta T, Takeshige K (2001). "A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei". J. Biol. Chem. 276 (29): 27657–62. doi:10.1074/jbc.M103426200. PMID 11356851.
• Kitamura H, Kanehira K, Shiina T, Morimatsu M, Jung BD, Akashi S, Saito M (2002). "Bacterial lipopolysaccharide induces mRNA expression of an IkappaB MAIL through toll-like receptor 4". J. Vet. Med. Sci. 64 (5): 419–22. doi:10.1292/jvms.64.419. PMID 12069074.
• Kitamura H, Matsushita Y, Iwanaga T, Mori K, Kanehira K, Fujikura D, Morimatsu M, Saito M (2003). "Bacterial lipopolysaccharide-induced expression of the IkappaB protein MAIL in B-lymphocytes and macrophages". Arch. Histol. Cytol. 66 (1): 53–62. doi:10.1679/aohc.66.53. PMID 12703554.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shiina T, Konno A, Oonuma T, Kitamura H, Imaoka K, Takeda N, Todokoro K, Morimatsu M (2004). "Targeted disruption of MAIL, a nuclear IkappaB protein, leads to severe atopic dermatitis-like disease". J. Biol. Chem. 279 (53): 55493–8. doi:10.1074/jbc.M409770200. PMID 15491998.
• Ito T, Morimatsu M, Oonuma T, Shiina T, Kitamura H, Syuto B (2004). "Transcriptional regulation of the MAIL gene in LPS-stimulated RAW264 mouse macrophages". Gene. 342 (1): 137–43. doi:10.1016/j.gene.2004.07.032. PMID 15527973.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Yamamoto M, Yamazaki S, Uematsu S, et al. (2004). "Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta". Nature. 430 (6996): 218–22. doi:10.1038/nature02738. PMID 15241416.
• Yamaji D, Kitamura H, Kimura K, Matsushita Y, Okada H, Shiina T, Morimatsu M, Saito M (2004). "Cloning of bovine MAIL and its mRNA expression in white blood cells of Holstein cows". Vet. Immunol. Immunopathol. 98 (3–4): 175–84. doi:10.1016/j.vetimm.2003.12.004. PMID 15010226.
• Yamazaki S, Muta T, Matsuo S, Takeshige K (2005). "Stimulus-specific induction of a novel nuclear factor-kappaB regulator, IkappaB-zeta, via Toll/Interleukin-1 receptor is mediated by mRNA stabilization". J. Biol. Chem. 280 (2): 1678–87. doi:10.1074/jbc.M409983200. PMID 15522867.
• Motoyama M, Yamazaki S, Eto-Kimura A, et al. (2005). "Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein". J. Biol. Chem. 280 (9): 7444–51. doi:10.1074/jbc.M412738200. PMID 15618216.
• Cowland JB, Muta T, Borregaard N (2006). "IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta". J. Immunol. 176 (9): 5559–66. doi:10.4049/jimmunol.176.9.5559. PMID 16622025.
• Oonuma T, Morimatsu M, Ochiai K, Iwanaga T, Hashizume K (2007). "Role of NF-kappaB in constitutive expression of MAIL in epidermal keratinocytes". J Vet Med Sci. 69 (3): 279–84. doi:10.1292/jvms.69.279. PMID 17409644.
• Matsuo S, Yamazaki S, Takeshige K, Muta T (2007). "Crucial roles of binding sites for NF-kappaB and C/EBPs in IkappaB-zeta-mediated transcriptional activation". Biochem. J. 405 (3): 605–15. doi:10.1042/BJ20061797. PMC 2267307. PMID 17447895.