NRP2

Neuropilin 2
Identifiers
Symbols	NRP2 ; NP2; MGC126574; NPN2; PRO2714; VEGF165R2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2875
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NRP2 210841 s at tn.png
File:PBB GE NRP2 219367 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Neuropilin 2, also known as NRP2, is a human gene.

This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Further reading

• Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z (1999). "Vascular endothelial growth factor (VEGF) and its receptors". FASEB J. 13 (1): 9–22. PMID 9872925.CS1 maint: Multiple names: authors list (link)
• Kolodkin AL, Levengood DV, Rowe EG; et al. (1997). "Neuropilin is a semaphorin III receptor". Cell. 90 (4): 753–62. PMID 9288754.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen H, Chédotal A, He Z; et al. (1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron. 19 (3): 547–59. PMID 9331348.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Giger RJ, Urquhart ER, Gillespie SK; et al. (1999). "Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity". Neuron. 21 (5): 1079–92. PMID 9856463.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen H, He Z, Bagri A, Tessier-Lavigne M (1999). "Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins". Neuron. 21 (6): 1283–90. PMID 9883722.CS1 maint: Multiple names: authors list (link)
• Takahashi T, Nakamura F, Jin Z; et al. (1999). "Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors". Nat. Neurosci. 1 (6): 487–93. doi:10.1038/2203. PMID 10196546.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rossignol M, Beggs AH, Pierce EA, Klagsbrun M (1999). "Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively". Genomics. 57 (3): 459–60. doi:10.1006/geno.1999.5790. PMID 10329017.CS1 maint: Multiple names: authors list (link)
• Tamagnone L, Artigiani S, Chen H; et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. PMID 10520995.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (2000). "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]". J. Biol. Chem. 275 (24): 18040–5. doi:10.1074/jbc.M909259199. PMID 10748121.CS1 maint: Multiple names: authors list (link)
• Handa A, Tokunaga T, Tsuchida T; et al. (2000). "Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma". Int. J. Oncol. 17 (2): 291–5. PMID 10891538.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rossignol M, Gagnon ML, Klagsbrun M (2001). "Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms". Genomics. 70 (2): 211–22. doi:10.1006/geno.2000.6381. PMID 11112349.CS1 maint: Multiple names: authors list (link)
• Gluzman-Poltorak Z, Cohen T, Shibuya M, Neufeld G (2001). "Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes". J. Biol. Chem. 276 (22): 18688–94. doi:10.1074/jbc.M006909200. PMID 11278319.CS1 maint: Multiple names: authors list (link)
• Cohen T, Gluzman-Poltorak Z, Brodzky A; et al. (2001). "Neuroendocrine cells along the digestive tract express neuropilin-2". Biochem. Biophys. Res. Commun. 284 (2): 395–403. doi:10.1006/bbrc.2001.4958. PMID 11394892.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Herzog Y, Kalcheim C, Kahane N; et al. (2002). "Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins". Mech. Dev. 109 (1): 115–9. PMID 11677062.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oh H, Takagi H, Otani A; et al. (2002). "Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 383–8. doi:10.1073/pnas.012074399. PMID 11756651.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fakhari M, Pullirsch D, Abraham D; et al. (2002). "Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma". Cancer. 94 (1): 258–63. PMID 11815985.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cohen T, Herzog Y, Brodzky A; et al. (2002). "Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumours". J. Pathol. 198 (1): 77–82. doi:10.1002/path.1179. PMID 12210066.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kawakami T, Tokunaga T, Hatanaka H; et al. (2003). "Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma". Cancer. 95 (10): 2196–201. doi:10.1002/cncr.10936. PMID 12412174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)