Necrotizing fasciitis Biopsy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yamuna Kondapally, M.B.B.S[2]
Overview
On frozen section biopsy, histologic criteria for diagnosis of necrotizing fasciitis include necrosis of superficial fascia, fibrinous thrombi of arteries and veins, polymorphonuclear infiltration of the dermis and fascia, and presence of microorganisms within the destroyed fascia and dermis.
Frozen Section Biopsy
Specimens are taken from advancing edge and central necrotic areas for good yield. These tissues are used for tissue culture and microscopic histopathology.[1]
- The histologic criteria for diagnosis of necrotizing fasciitis include:
- Necrosis of superficial fascia
- Fibrinous thrombi of arteries and veins
- Polymorphonuclear infiltration of the dermis and fascia
- Angitis with fibrinoid necrosis of arterial and venous walls
- Absence of muscle
- Presence of microorganisms within the destroyed fascia and dermis
References
- ↑ Stamenkovic I, Lew PD (1984). "Early recognition of potentially fatal necrotizing fasciitis. The use of frozen-section biopsy". N Engl J Med. 310 (26): 1689–93. doi:10.1056/NEJM198406283102601. PMID 6727947.