Neutrophil gelatinase-associated lipocalin

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Synonyms and keywords: NGAL

  • Neutrophil gelatinase-associated lipocalin (NGAL), from the family of lipocalins, is a polypeptide that is secreted following renal tubular cell injury.[1] [2] [3]
  • Elevated NGAL levels in the urine and plasma can be used as a useful biomarker for early diagnosis of AKI before creatinine rise or changes in urinary output.[3]
  • NGAL level is correlated with the severity of AKI.[3]

References

  1. ↑ Devarajan P (2008). "Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of kidney disease". Scand J Clin Lab Invest Suppl. 241: 89–94. doi:10.1080/00365510802150158. PMC 2528839. PMID 18569973.
  2. ↑ Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, Yang J; et al. (2003). "Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury". J Am Soc Nephrol. 14 (10): 2534–43. doi:10.1097/01.asn.0000088027.54400.c6. PMID 14514731.
  3. ↑ 3.0 3.1 3.2 Shang W, Wang Z (2017). "The Update of NGAL in Acute Kidney Injury". Curr Protein Pept Sci. 18 (12): 1211–1217. doi:10.2174/1389203717666160909125004. PMID 27634444.
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