Noncompaction cardiomyopathy biopsy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Both skeletal and cardiac biopsies may reveal abnormal histologic findings.

A skeletal biopsy can be performed which may demonstrate inclusion bodies or myopathic changes ^[1].

Interstitial fibrosis was observed in 5/5 patients with isolated noncompaction cardiomyopathy who underwent right ventricular biopsy^[2]
Endomyocardial thickening and subendocardial fibroelastosis was observed in 3/5 patients who underwent right ventricular biopsy.
Myocyte necrosis has been observed in areas of trabeculation ^[3]^[4].

↑ Botto, LD. Left ventricular noncompaction. Orphanet encyclopedia. http://www.orpha.net/data/patho/GB/uk-LVNC.pdf
↑ Hamamichi Y, Ichida F, Hashimoto I, et al. Isolated noncompaction of the ventricular myocardium: ultrafast computer tomography and magnetic resonance imaging. Int J Cardiovasc Imaging. 2001; 17: 305–314.
↑ Oechslin EN, Attenhofer Jost CH, Rojas JR, et al. Long-term follow-up of 34 adults with isolated left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis. J Am Coll Cardiol. 2000; 36: 493–500.
↑ Finsterer J, Stollberger C, Feichtinger H. Histological appearance of left ventricular hypertrabeculation/noncompaction. Cardiology. 2002; 98: 162–164.