Nudix hydrolase 15

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Nudix hydrolase 15 is a protein that in humans is encoded by the NUDT15 gene.

Function

This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016].

Further reading

• Yu Y, Cai JP, Tu B, Wu L, Zhao Y, Liu X, Li L, McNutt MA, Feng J, He Q, Yang Y, Wang H, Sekiguchi M, Zhu WG (July 2009). "Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2". J. Biol. Chem. 284 (29): 19310–20. doi:10.1074/jbc.M109.015289. PMC 2740556. PMID 19419956.
• Hori M, Satou K, Harashima H, Kamiya H (May 2010). "Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5". Free Radic. Biol. Med. 48 (9): 1197–201. doi:10.1016/j.freeradbiomed.2010.02.002. PMID 20144704.
• Yang SK, Hong M, Baek J, Choi H, Zhao W, Jung Y, Haritunians T, Ye BD, Kim KJ, Park SH, Park SK, Yang DH, Dubinsky M, Lee I, McGovern DP, Liu J, Song K (September 2014). "A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia". Nat. Genet. 46 (9): 1017–20. doi:10.1038/ng.3060. PMC 4999337. PMID 25108385.
• Yang JJ, Landier W, Yang W, Liu C, Hageman L, Cheng C, Pei D, Chen Y, Crews KR, Kornegay N, Wong FL, Evans WE, Pui CH, Bhatia S, Relling MV (April 2015). "Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia". J. Clin. Oncol. 33 (11): 1235–42. doi:10.1200/JCO.2014.59.4671. PMC 4375304. PMID 25624441.
• Tanaka Y, Kato M, Hasegawa D, Urayama KY, Nakadate H, Kondoh K, Nakamura K, Koh K, Komiyama T, Manabe A (October 2015). "Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia". Br. J. Haematol. 171 (1): 109–15. doi:10.1111/bjh.13518. PMID 26033531.
• Kakuta Y, Naito T, Onodera M, Kuroha M, Kimura T, Shiga H, Endo K, Negoro K, Kinouchi Y, Shimosegawa T (June 2016). "NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD". Pharmacogenomics J. 16 (3): 280–5. doi:10.1038/tpj.2015.43. PMID 26076924.
• Carter M, Jemth AS, Hagenkort A, Page BD, Gustafsson R, Griese JJ, Gad H, Valerie NC, Desroses M, Boström J, Warpman Berglund U, Helleday T, Stenmark P (August 2015). "Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2". Nat Commun. 6: 7871. doi:10.1038/ncomms8871. PMC 4532830. PMID 26238318.
• Chiengthong K, Ittiwut C, Muensri S, Sophonphan J, Sosothikul D, Seksan P, Suppipat K, Suphapeetiporn K, Shotelersuk V (January 2016). "NUDT15 c.415C>T increases risk of 6-mercaptopurine induced myelosuppression during maintenance therapy in children with acute lymphoblastic leukemia". Haematologica. 101 (1): e24–6. doi:10.3324/haematol.2015.134775. PMC 4697903. PMID 26405151.
• Liang DC, Yang CP, Liu HC, Jaing TH, Chen SH, Hung IJ, Yeh TC, Lin TH, Lai CL, Lai CY, Shih LY (November 2016). "NUDT15 gene polymorphism related to mercaptopurine intolerance in Taiwan Chinese children with acute lymphoblastic leukemia". Pharmacogenomics J. 16 (6): 536–539. doi:10.1038/tpj.2015.75. PMID 26503813.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.