ODC1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Ornithine decarboxylase is an enzyme that in humans is encoded by the ODC1 gene.

This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter.

Further reading

• Pegg AE (2006). "Regulation of ornithine decarboxylase". J. Biol. Chem. 281 (21): 14529–32. doi:10.1074/jbc.R500031200. PMID 16459331.
• Yoshida M, Hayashi H, Taira M, Isono K (1992). "Elevated expression of the ornithine decarboxylase gene in human esophageal cancer". Cancer Res. 52 (23): 6671–5. PMID 1423312.
• Moshier JA, Osborne DL, Skunca M, et al. (1992). "Multiple promoter elements govern expression of the human ornithine decarboxylase gene in colon carcinoma cells". Nucleic Acids Res. 20 (10): 2581–90. doi:10.1093/nar/20.10.2581. PMC 312396. PMID 1598217.
• Hickok NJ, Wahlfors J, Crozat A, et al. (1990). "Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudogene". Gene. 93 (2): 257–63. doi:10.1016/0378-1119(90)90233-H. PMID 2227439.
• Hsieh JT, Denning MF, Heidel SM, Verma AK (1990). "Expression of human chromosome 2 ornithine decarboxylase gene in ornithine decarboxylase-deficient Chinese hamster ovary cells". Cancer Res. 50 (8): 2239–44. PMID 2317811.
• Moshier JA, Gilbert JD, Skunca M, et al. (1990). "Isolation and expression of a human ornithine decarboxylase gene". J. Biol. Chem. 265 (9): 4884–92. PMID 2318872.
• Verrando P, Juhlin L, Lacour JP, Ortonne JP (1987). "Immunohistochemical localization of ornithine decarboxylase in human skin". J. Dermatol. 14 (2): 112–7. PMID 2440930.
• van Steeg H, van Oostrom CT, Martens JW, et al. (1989). "Nucleotide sequence of the human ornithine decarboxylase gene". Nucleic Acids Res. 17 (21): 8855–6. doi:10.1093/nar/17.21.8855. PMC 335049. PMID 2587220.
• Fitzgerald MC, Flanagan MA (1990). "Characterization and sequence analysis of the human ornithine decarboxylase gene". DNA. 8 (9): 623–34. doi:10.1089/dna.1.1989.8.623. PMID 2693021.
• Alhonen-Hongisto L, Leinonen P, Sinervirta R, et al. (1987). "Mouse and human ornithine decarboxylase genes. Methylation polymorphism and amplification". Biochem. J. 242 (1): 205–10. PMC 1147684. PMID 3036086.
• Kaczmarek L, Calabretta B, Ferrari S, de Riel JK (1987). "Cell-cycle-dependent expression of human ornithine decarboxylase". J. Cell. Physiol. 132 (3): 545–51. doi:10.1002/jcp.1041320318. PMID 3308908.
• Hickok NJ, Seppänen PJ, Gunsalus GL, Jänne OA (1987). "Complete amino acid sequence of human ornithine decarboxylase deduced from complementary DNA". DNA. 6 (3): 179–87. doi:10.1089/dna.1987.6.179. PMID 3595418.
• Winqvist R, Mäkelä TP, Seppänen P, et al. (1986). "Human ornithine decarboxylase sequences map to chromosome regions 2pter----p23 and 7cen----qter but are not coamplified with the NMYC oncogene". Cytogenet. Cell Genet. 42 (3): 133–40. doi:10.1159/000132266. PMID 3755388.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
• Kim YJ, Pan H, Verma AK (1994). "Non-AP-1 tumor promoter 12-O-tetradecanoylphorbol-13-acetate-responsive sequences in the human ornithine decarboxylase gene". Mol. Carcinog. 10 (3): 169–79. doi:10.1002/mc.2940100308. PMID 8043198.
• Müller M, Pajunen AE, Järvinen M, et al. (1994). "Immunohistochemical demonstration of L-ornithine decarboxylase enzyme protein in different areas of the developing human brain". Dev. Neurosci. 15 (2): 87–93. doi:10.1159/000111320. PMID 8168440.
• Ichiba T, Matsufuji S, Miyazaki Y, et al. (1994). "Functional regions of ornithine decarboxylase antizyme". Biochem. Biophys. Res. Commun. 200 (3): 1721–7. doi:10.1006/bbrc.1994.1651. PMID 8185631.
• Wright PS, Cooper JR, Cross-Doersen DE, et al. (1996). "Regulation of ornithine decarboxylase mRNA levels in human breast cancer cells: pattern of expression and involvement of core enhancer promoter element". Cell Growth Differ. 6 (9): 1097–102. PMID 8519686.
• Heiskala M, Zhang J, Hayashi S, et al. (1999). "Translocation of ornithine decarboxylase to the surface membrane during cell activation and transformation". EMBO J. 18 (5): 1214–22. doi:10.1093/emboj/18.5.1214. PMC 1171212. PMID 10064588.
• Pomidor MM, Cimildoro R, Lazatin B, et al. (2000). "Phosphorylated human keratinocyte ornithine decarboxylase is preferentially associated with insoluble cellular proteins". Mol. Biol. Cell. 10 (12): 4299–310. doi:10.1091/mbc.10.12.4299. PMC 25759. PMID 10588659.
• Symes AJ, Eilertsen M, Millar M, et al. (2013). "Quantitative Analysis of BTF3, HINT1, NDRG1 and ODC1 Protein Over-Expression in Human Prostate Cancer Tissue". PLoS ONE. 8 (12): e84295. doi:10.1371/journal.pone.0084295. PMC 3874000. PMID 24386364.