ORC2L

Origin recognition complex, subunit 2-like (yeast)
Identifiers
Symbols	ORC2L ; ORC2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4512
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE ORC2L 204853 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Origin recognition complex, subunit 2-like (yeast), also known as ORC2L, is a human gene.

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3L, -4L, and -5L. It also interacts with CDC45L and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication.

Further reading

• Gavin KA, Hidaka M, Stillman B (1996). "Conserved initiator proteins in eukaryotes". Science. 270 (5242): 1667–71. PMID 7502077.CS1 maint: Multiple names: authors list (link)
• Takahara K, Bong M, Brevard R; et al. (1996). "Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L". Genomics. 31 (1): 119–22. doi:10.1006/geno.1996.0018. PMID 8808289.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Quintana DG, Hou Zh, Thome KC; et al. (1997). "Identification of HsORC4, a member of the human origin of replication recognition complex". J. Biol. Chem. 272 (45): 28247–51. PMID 9353276.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saha P, Thome KC, Yamaguchi R; et al. (1998). "The human homolog of Saccharomyces cerevisiae CDC45". J. Biol. Chem. 273 (29): 18205–9. PMID 9660782.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ritzi M, Baack M, Musahl C; et al. (1998). "Human minichromosome maintenance proteins and human origin recognition complex 2 protein on chromatin". J. Biol. Chem. 273 (38): 24543–9. PMID 9733749.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Quintana DG, Thome KC, Hou ZH; et al. (1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases". J. Biol. Chem. 273 (42): 27137–45. PMID 9765232.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pinto S, Quintana DG, Smith P; et al. (1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron. 23 (1): 45–54. PMID 10402192.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jiang W, McDonald D, Hope TJ, Hunter T (1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication". EMBO J. 18 (20): 5703–13. doi:10.1093/emboj/18.20.5703. PMID 10523313.CS1 maint: Multiple names: authors list (link)
• Natale DA, Li CJ, Sun WH, DePamphilis ML (2000). "Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals". EMBO J. 19 (11): 2728–38. doi:10.1093/emboj/19.11.2728. PMID 10835370.CS1 maint: Multiple names: authors list (link)
• Thome KC, Dhar SK, Quintana DG; et al. (2001). "Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins". J. Biol. Chem. 275 (45): 35233–41. doi:10.1074/jbc.M005765200. PMID 10954718.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Izumi M, Yanagi K, Mizuno T; et al. (2001). "The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase". Nucleic Acids Res. 28 (23): 4769–77. PMID 11095689.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vashee S, Simancek P, Challberg MD, Kelly TJ (2001). "Assembly of the human origin recognition complex". J. Biol. Chem. 276 (28): 26666–73. doi:10.1074/jbc.M102493200. PMID 11323433.CS1 maint: Multiple names: authors list (link)
• Dhar SK, Delmolino L, Dutta A (2001). "Architecture of the human origin recognition complex". J. Biol. Chem. 276 (31): 29067–71. doi:10.1074/jbc.M103078200. PMID 11395502.CS1 maint: Multiple names: authors list (link)
• Dhar SK, Yoshida K, Machida Y; et al. (2001). "Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin". Cell. 106 (3): 287–96. PMID 11509178.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Izumi M, Yatagai F, Hanaoka F (2002). "Cell cycle-dependent proteolysis and phosphorylation of human Mcm10". J. Biol. Chem. 276 (51): 48526–31. doi:10.1074/jbc.M107190200. PMID 11602595.CS1 maint: Multiple names: authors list (link)
• Fujita M, Ishimi Y, Nakamura H; et al. (2002). "Nuclear organization of DNA replication initiation proteins in mammalian cells". J. Biol. Chem. 277 (12): 10354–61. doi:10.1074/jbc.M111398200. PMID 11779870.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schaarschmidt D, Ladenburger EM, Keller C, Knippers R (2002). "Human Mcm proteins at a replication origin during the G1 to S phase transition". Nucleic Acids Res. 30 (19): 4176–85. PMID 12364596.CS1 maint: Multiple names: authors list (link)
• Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M (2002). "Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication". Biochim. Biophys. Acta. 1578 (1–3): 59–72. PMID 12393188.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kneissl M, Pütter V, Szalay AA, Grummt F (2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. PMID 12614612.CS1 maint: Multiple names: authors list (link)