Osteoid osteoma

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For more information about osteoma that is not associated with osteoid osteoma, see osteoma

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rohan A. Bhimani, M.B.B.S., D.N.B., M.Ch.[2]

Synonyms and keywords: Osteoma osteoid; OO; Osteoid osteomas

Overview

Osteoid osteoma is the third most common benign bone tumor. Its incidence is 11% among the benign tumors and 3% among all primary bone tumors. Adolescents and children are most affected by osteoid osteoma. Men are more commonly affected than women, with a 6:4 ratio. Osteoid osteoma is a benign osteoblastic tumor that was first described in 1930 by Bergstrand. Jaffe described it in 1935 and was the first to recognize it as a unique entity. Osteoid osteomas are usually smaller than 1.5-2 cm and characterized by an osteoid-rich nidus in a highly loose, vascular connective tissue. The nidus is well demarcated and may contain a variable amount of calcification. Surrounding the nidus is a zone of sclerotic but otherwise normal bone. Osteoid osteoma can occur anywhere. Osteoid osteoma is usually occur in the cortex of the shafts of long bones more than 50% of the cases. It is seen in the metaphyseal regions of large bones of the femur, tibia, and humerus. About 20% percent of the lesions involve posterior element of the spine. The hallmark of osteoid osteoma is intense nocturnal limb pain which is relieved by low doses of salicylates and local tenderness. If left untreated, osteoid osteoma progression occurs slow and is then followed by restricted range of motion, possible pathologic fracture, or spontaneous regression. The medical therapy for osteoid osteoma is NSAIDs and the mainstay of treatment is surgery.

Historical Perspective

• In 1930, Dr. Bergstrand, a German physician, first described osteoid osteoma in 1930.
• In 1935, Dr.Henry Jaffe, an American pathologist first described osteoid osteoma as a benign bone tumor.
• In 1953, Dr. Jaffe coined the term nidus, which was described as the “core”, referring to the tumor itself and is composed of bone at various stages of maturity within a highly vascular connective tissue stroma.
• In 1954, Dahlin and Johnson added the term giant osteoid osteomas.
• In 1966, Dr.Edeiken classified osteoid osteomas into three types.

Classification

• Osteoid Osteoma can be classified based on location and imaging findings.

Anatomical Classification

• Based on Location:

Type of osteoid osteoma	Characteristics
Intracortical	Dense sclerosis around the nidus
Periosteal	Periosteal reaction
Cancellous (medullary)	Produces very little reactive bone
Subarticular	Simulates arthritis as it produces synovial reactions

Enneking (MSTS) Staging System

• The Enneking surgical staging system (also known as the MSTS system) for benign musculoskeletal tumors based on radiographic characteristics of the tumor host margin.
• It is widely accepted and routinely used classification.

Stages	Description
1	Latent: Well demarcated borders
2	Active: Indistinct borders
3	Aggressive: Indistinct borders

Pathophysiology

• The exact etiology of osteoid osteoma is unknown.
• Osteoid osteoma arises from the osteoblasts.
• Osteoid osteoma consists of radially oriented trabeculae of surrounding reactive bone, indicating an increased pressure in the vascular nidus.
• This arrangement of the bony trabeculae is due to the stresses placed on them.
• This increased pressure is due to vasodilatation and edema is which stimulate interosseous nerve endings, generating pain.
• In addition, the pain is also attributed to increased local concentration of prostaglandin E2, COX1 & 2 expression; and increased number and size of unmyelinated nerve fibers within the nidus.
• Osteoid osteomas are usually cortical lesions but they can occur anywhere within the bone including medullary, subperiosteal (most common in talus), and intracapsular area.
• More than 50 percent of osteoid osteomas occur in lower extremity of long bones.
• It most commonly affects the metadiaphysis of the femur and tibia.
• About 20 percent of osteoid osteomas occur in the posterior elements of the spine.

Genetics

• The structural chromosomal alterations involving 22q13.1 in osteoid osteoma may affect critical genes involved in the regulation of cell proliferation, such as the YWHAH gene.
• YWHAH gene codes for a 14-3-3 family members of dimeric phosphoserine-binding proteins that participate in signal transduction and checkpoint control pathways.
• Their primary function is to inhibit apoptosis.
• Another gene mapped in this region is PDGFB that codes for a platelet-derived growth factor, a beta polypeptide (simian sarcoma viral [v-sis] oncogene homolog), a potent mitogen for cells of mesenchymal origin and involved in the transformation process.

Causes

• The cause of osteoid osteoma has not been identified.

Differentiating Osteoid osteoma from Other Diseases

• Osteoid osteoma must be differentiated from other diseases that cause night-pain, soft tissue swelling, and bowing deformity such as other osteogenic tumors, osteoblastoma, bone abscess (Brodie abscess), osteosarcoma, and enostosis.

Differential Diagnosis	Similar Features	Differentiating Features
Osteoblastoma	Benign, male predilection, and also present in long bones	In osteoblastoma, differentiating features include uncommon tumor, affect the axial skeleton more frequently, lesions are typically larger than 2 cm, but more importantly, osteoid osteoma can only be distinguished from osteoblastoma by imaging features
Brodie abscess	Present in children, limb pain, and occasionally affects long bones	In Brodie abscess, differentiating features include: fever, subacute onset, and the location usually affects the metaphysis of tubular bones
Osteosarcoma	Affects the same group of population (children and adolescents), patients usually present with bone pain, and the location is usually long bones	In osteosarcoma, differentiating features include: malignancy, infiltration to surrounding tissue, and elevation of serum alkaline phosphatase (ALP)
Enostosis	Affects the same group of population (children and adolescents), small size, and the location is usually long bones	In enostosis, differentiating features, include: Pathognomonic radiological appearance and incidental finding

Epidemiology and Demographics

• Osteoid osteoma is the third most common benign bone tumor.
• Its incidence is 11% among the benign tumors and 3% among all primary bone tumors.
• Adolescents and children are most affected by osteoid osteoma.
• The age distribution of osteoid osteoma is between 5-22 years.
• The mean age of the patients with osteoid osteoma is 12 years.
• Men are more commonly affected than women, with a 6:4 ratio.
• There is no racial predilection to osteoid osteoma.

Risk Factors

• There are no established risk factors for osteoid osteoma.

Screening

• There is insufficient evidence to recommend routine screening for osteoid osteoma.

Natural History, Complications, and Prognosis

• The natural history of untreated osteoid osteoma is toward spontaneous regression, it is taken an average of 6 years.
• During this period, the nidus gradually begins to calcify; afterwards, ossify, and, finally, blends into sclerotic surrounding bone.
• The local pain gradually diminishes over time.
• Common complications of osteoid osteoma includes pathological fracture, stress fracture, and muscle atrophy.
• Prognosis is generally excellent after surgery.
• Local recurrence is rare but may occur 6 months after surgery.

Diagnosis

Diagnostic Study of Choice

• CT scan is the diagnostic study of choice for the diagnosis of osteoid osteoma.
• CT scan findings include:
  • Sharp round lesion which is less than 2 cm in diameter.
  • Osteoid osteoma has a homogeneous dense center.
  • Sclerotic reactive bone surrounding the nidus is seen.
  • A 1.5 mm peripheral radiolucent zone is seen.
  • Furthermore, a central sclerotic is noted.

History and Symptoms

• The majority of patients with osteoid osteoma have localized pain that worsens at night.
• The pain is relieved by salicylates.
• Swelling
• Intra-articular lesions present with:
  • Limb deformity
  • Abnormal gait
• Lesions involving spine present as back pain.

Physical Examination

• Patients with osteoid osteoma usually appears well.
• Common physical examination findings of osteoid osteoma include:
  • Palpable bone deformity
  • Swelling
  • Erythema
  • Tenderness
• If the lesion is in proximity to a joint, findings include:
  • Effusion
  • Contracture
  • Abnormal gait
  • Muscle atrophy
• If the lesion involves spine, findings include:
  • Postural scoliosis
  • Paravertebral muscle spasm

Laboratory Findings

• There are no diagnostic laboratory findings associated with osteoid osteoma.

X-ray of osteoid osteoma: A well circumscribed lucent region with a central sclerotic dot.Source: Case courtesy of A.Prof Frank Gaillard, Radiopaedia.org, rID: 28806

Electrocardiogram

• There are no ECG findings associated with osteoid osteoma.

X-ray

• Three views of affected bone or joint are recommended.
• Radiological findings for osteoid osteoma include:
  • Intensely reactive bone
  • Radiolucent nidus

Echocardiography or Ultrasound

• Ultrasound findings associated with osteoid osteoma, include:
  • Focal cortical irregularity
  • Adjacent hypoechoic synovitis
  • Hypoechogenicity with posterior acoustic enhancement
  • On Doppler ultrasound, osteoid osteoma may appear as a hypervascular nidus.

CT scan

CT scan of osteoid osteoma showing a lucent nidus on proximal femur.Source: Case courtesy of A.Prof Frank Gaillard, Radiopaedia.org, rID: 28806

• CT scan is the study of choice for the diagnosis of osteoid osteoma.
• CT findings include:
  • Sharp round lesion which is less than 2 cm in diameter.
  • Osteoid osteoma has a homogeneous dense center.
  • Sclerotic reactive bone surrounding the nidus is seen.
  • A 1.5 mm peripheral radiolucent zone is seen.
  • Furthermore, a central sclerotic is noted.

MRI

• MRI is usually not recommended as it can mimic aggressive lesions.
• MRI is more sensitive than CT scan for detection of reactive changes in osteoid osteoma patients.
• MRI may be helpful in the visualizing the nidus especially in the cortex and medullary zone of the bone.
• Visualizing nidus depends on the mineralization and its vascularity of the lesion and it can be hypointense in appearance.
• The reactive changes in osteoid osteoma patients on MRI can look like half-moon sign.
• The presence of half-moon sign in femoral neck is an indication and highly specific for osteoid osteoma.

Radionuclide Scanning

• Radionuclide scans are reliable tools when radiographic findings are not diagnostic.
• Bone scan findings include:
  • Intense hot area of focal uptake at the nidus.
  • Low uptake in reactive zone known as the double-density sign.

Other Diagnostic Studies

Osteoid Osteoma Gross Appearnace.Source: Case courtesy of A.Prof Frank Gaillard, Radiopaedia.org, rID: 28806

Osteoid Osteoma histology.[Source: By No machine-readable author provided. Nephron assumed (based on copyright claims). - No machine-readable source provided. Own work assumed (based on copyright claims)., CC BY-SA 3.0]

Biopsy

• Biopsy may be helpful in the diagnosis of osteoid osteoma.
• Biopsy demonstrates the following features:
  • Nidus usually about 1.5-2 cms, brownish-red, mottled, and gritty lesion that is distinct from the surrounding bone.
  • Network of interconnecting bone, widened vessels, osteoblasts, and bone matrix
  • Fibrinoid margin with areas of angiogenesis
  • Adjacent sclerosis
• On histological examination:
  • Osteoid and woven bone lined with osteoblasts and richly innervated with surrounding hypervascular connective tissue with osteoclasts is seen.
• Osteoid osteoma do not malignantly transform.

Treatment

Medical Therapy

• Clinical observation and NSAID administration.
  • NSAIDs are 1st line and will lead to a dramatic decrease in symptoms.
  • About 50% of the patients can be treated with NSAIDs alone.
  • NSAIDs are also indicated for painful spine lesions without scoliosis.
  • The natural course of osteoid osteomas is spontaneous regression. However, NSAIDs may accelerate this process.
  • Fingertip lesions (distal phalanx) may not respond to NSAIDs.

Surgery

Surgery is the mainstay of treatment for osteoid osteoma.

Percutaneous Radiofrequency Ablation (RFA)

Indications

• Failure of medical management
• Periarticular lesions which increase the risk of cartilage injury and premature degenerative disease
• Spinal lesions depending on the location of the lesion and proximity to neural elements

Contraindications

• Lesions close to spinal cord or nerve roots

Technique

• It is done under CT guidance
• Probing is done at 80-90 degree C for 6 minutes to produce a 1cm zone of necrosis

Outcomes

• 90% of patients are successfully treated with 1-2 sessions of radiofrequency ablation (RFA).
• 10-15% recurrence rate.

Surgical Resection with Curettage

Indications

• When location of lesion is not amenable to CT guided percutaneous radiofrequency ablation such as close to skin or nerve.
• Spine lesion associated with painful scoliosis.
• Digital lesions because RFA carries risk of thermal skin necrosis and injury to digital neurovascular bundle.

Technique

• Successful treatment depends on complete marginal resection of nidus.
• Sclerotic bone is normal and can be left behind.
• It can be done by:
  • Percutaneous approach
  • Open approach

Outcomes

• 94% success with local excision.

Primary Prevention

• There are no established measures for the primary prevention of osteoid osteoma.

Secondary Prevention

• There are no established measures for the secondary prevention of osteoid osteoma.

References

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