Prostaglandin E2 receptor
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| Prostaglandin E receptor 2 (subtype EP2), 53kDa | |||||||||||
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| Identifiers | |||||||||||
| Symbols | PTGER2 ; EP2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 739 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE PTGER2 206631 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Prostaglandin E2 receptor (53kDa), also known as PTGER2, subtype EP2 or Prostaglandin E receptor 2, is a prostaglandin receptor for prostaglandin E2. It also denotes the human gene encoding the receptor.[1]
Mechanism
The receptor is a G-protein coupled receptor, which activates the G protein Gs.[2].
See also
References
Further reading
- Duncan AM, Anderson LL, Funk CD; et al. (1995). "Chromosomal localization of the human prostanoid receptor gene family". Genomics. 25 (3): 740–2. PMID 7759114.
- Regan JW, Bailey TJ, Pepperl DJ; et al. (1994). "Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype". Mol. Pharmacol. 46 (2): 213–20. PMID 8078484.
- Bastien L, Sawyer N, Grygorczyk R; et al. (1994). "Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype". J. Biol. Chem. 269 (16): 11873–7. PMID 8163486.
- An S, Yang J, Xia M, Goetzl EJ (1994). "Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2". Biochem. Biophys. Res. Commun. 197 (1): 263–70. PMID 8250933.
- Stillman BA, Breyer MD, Breyer RM (1999). "Importance of the extracellular domain for prostaglandin EP(2) receptor function". Mol. Pharmacol. 56 (3): 545–51. PMID 10462542.
- Smock SL, Pan LC, Castleberry TA; et al. (1999). "Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E(2) receptor EP2 subtype". Gene. 237 (2): 393–402. PMID 10521663.
- Desai S, April H, Nwaneshiudu C, Ashby B (2001). "Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration". Mol. Pharmacol. 58 (6): 1279–86. PMID 11093764.
- Duckworth N, Marshall K, Clayton JK (2002). "An investigation of the effect of the prostaglandin EP2 receptor agonist, butaprost, on the human isolated myometrium from pregnant and non-pregnant women". J. Endocrinol. 172 (2): 263–9. PMID 11834444.
- Kyveris A, Maruscak E, Senchyna M (2002). "Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR". Mol. Vis. 8: 51–8. PMID 11951086.
- Takafuji VA, Evans A, Lynch KR, Roche JK (2003). "PGE(2) receptors and synthesis in human gastric mucosa: perturbation in cancer". Prostaglandins Leukot. Essent. Fatty Acids. 66 (1): 71–81. doi:10.1054/plef.2001.0299. PMID 12051958.
- Scandella E, Men Y, Gillessen S; et al. (2002). "Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells". Blood. 100 (4): 1354–61. doi:10.1182/blood-2001-11-0017. PMID 12149218.
- Okuyama T, Ishihara S, Sato H; et al. (2002). "Activation of prostaglandin E2-receptor EP2 and EP4 pathways induces growth inhibition in human gastric carcinoma cell lines". J. Lab. Clin. Med. 140 (2): 92–102. PMID 12228765.
- Konger RL, Scott GA, Landt Y; et al. (2003). "Loss of the EP2 prostaglandin E2 receptor in immortalized human keratinocytes results in increased invasiveness and decreased paxillin expression". Am. J. Pathol. 161 (6): 2065–78. PMID 12466123.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Abulencia JP, Gaspard R, Healy ZR; et al. (2003). "Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells". J. Biol. Chem. 278 (31): 28388–94. doi:10.1074/jbc.M301378200. PMID 12743126.
- Richards JA, Brueggemeier RW (2003). "Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes". J. Clin. Endocrinol. Metab. 88 (6): 2810–6. PMID 12788892.
- Sun HS, Hsiao KY, Hsu CC; et al. (2003). "Transactivation of steroidogenic acute regulatory protein in human endometriotic stromalcells is mediated by the prostaglandin EP2 receptor". Endocrinology. 144 (9): 3934–42. PMID 12933667.
- Bradbury DA, Newton R, Zhu YM; et al. (2004). "Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E2, E-prostanoid 2 (EP2), and EP4 receptors". J. Biol. Chem. 278 (50): 49954–64. doi:10.1074/jbc.M307964200. PMID 14517215.
- Moreland RB, Kim N, Nehra A; et al. (2004). "Functional prostaglandin E (EP) receptors in human penile corpus cavernosum". Int. J. Impot. Res. 15 (5): 362–8. doi:10.1038/sj.ijir.3901042. PMID 14562138.
- Sugimoto Y, Nakato T, Kita A; et al. (2004). "A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors". J. Biol. Chem. 279 (12): 11016–26. doi:10.1074/jbc.M307404200. PMID 14699136.
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