Thyrotropin-releasing hormone receptor

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Species	Human	Mouse
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The thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds the tripeptide thyrotropin releasing hormone.

The TRHR are found in the brain and when bound by TRH act (through phospholipase C) to increase intracellular inositol trisphosphate.

Further reading

• Short RE, James LF, Panter KE, Staigmiller RB, Bellows RA, Malcolm J, Ford SP (November 1992). "Effects of feeding ponderosa pine needles during pregnancy: comparative studies with bison, cattle, goats, and sheep". Journal of Animal Science. 70 (11): 3498–504. PMID 1459912.
• Yamada M, Iwasaki T, Satoh T, Monden T, Konaka S, Murakami M, Iriuchijima T, Mori M (August 1995). "Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly". Neuroscience Letters. 196 (1–2): 109–12. doi:10.1016/0304-3940(95)11861-P. PMID 7501234.
• Hinuma S, Hosoya M, Ogi K, Tanaka H, Nagai Y, Onda H (October 1994). "Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene". Biochimica et Biophysica Acta. 1219 (2): 251–9. doi:10.1016/0167-4781(94)90046-9. PMID 7918619.
• Morrison N, Duthie SM, Boyd E, Eidne KA, Connor JM (June 1994). "Assignment of the gene encoding the human thyrotropin-releasing hormone receptor to 8q23 by fluorescence in situ hybridization". Human Genetics. 93 (6): 716–8. doi:10.1007/bf00201580. PMID 8005602.
• Yamada M, Monden T, Konaka S, Mori M (November 1993). "Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8". Somatic Cell and Molecular Genetics. 19 (6): 577–80. doi:10.1007/BF01233384. PMID 8128317.
• Duthie SM, Taylor PL, Anderson L, Cook J, Eidne KA (September 1993). "Cloning and functional characterisation of the human TRH receptor". Molecular and Cellular Endocrinology. 95 (1–2): R11–5. doi:10.1016/0303-7207(93)90043-J. PMID 8243797.
• Matre V, Karlsen HE, Wright MS, Lundell I, Fjeldheim AK, Gabrielsen OS, Larhammar D, Gautvik KM (August 1993). "Molecular cloning of a functional human thyrotropin-releasing hormone receptor". Biochemical and Biophysical Research Communications. 195 (1): 179–85. doi:10.1006/bbrc.1993.2027. PMID 8395824.
• Yamada M, Monden T, Satoh T, Satoh N, Murakami M, Iriuchijima T, Kakegawa T, Mori M (September 1993). "Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene". Biochemical and Biophysical Research Communications. 195 (2): 737–45. doi:10.1006/bbrc.1993.2107. PMID 8396925.
• Iwasaki T, Yamada M, Satoh T, Konaka S, Ren Y, Hashimoto K, Kohga H, Kato Y, Mori M (September 1996). "Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene". The Journal of Biological Chemistry. 271 (36): 22183–8. doi:10.1074/jbc.271.36.22183. PMID 8703031.
• Cook JV, McGregor A, Lee T, Milligan G, Eidne KA (July 1996). "A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor". Endocrinology. 137 (7): 2851–8. doi:10.1210/en.137.7.2851. PMID 8770906.
• Collu R, Tang J, Castagné J, Lagacé G, Masson N, Huot C, Deal C, Delvin E, Faccenda E, Eidne KA, Van Vliet G (May 1997). "A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene". The Journal of Clinical Endocrinology and Metabolism. 82 (5): 1561–5. doi:10.1210/jc.82.5.1561. PMID 9141550.
• Petrou C, Tashjian AH (September 1998). "The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles". Cellular Signalling. 10 (8): 553–9. doi:10.1016/S0898-6568(97)00190-3. PMID 9794253.
• Matre V, Høvring PI, Orstavik S, Frengen E, Rian E, Velickovic Z, Murray-McIntosh RP, Gautvik KM (January 1999). "Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor". Journal of Neurochemistry. 72 (1): 40–50. doi:10.1046/j.1471-4159.1999.0720040.x. PMID 9886052.
• Kroeger KM, Hanyaloglu AC, Seeber RM, Miles LE, Eidne KA (April 2001). "Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer". The Journal of Biological Chemistry. 276 (16): 12736–43. doi:10.1074/jbc.M011311200. PMID 11278883.
• Zhu CC, Cook LB, Hinkle PM (August 2002). "Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation". The Journal of Biological Chemistry. 277 (31): 28228–37. doi:10.1074/jbc.M204221200. PMID 12023974.
• Hanyaloglu AC, Seeber RM, Kohout TA, Lefkowitz RJ, Eidne KA (December 2002). "Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2". The Journal of Biological Chemistry. 277 (52): 50422–30. doi:10.1074/jbc.M209340200. PMID 12393857.
• Cook LB, Zhu CC, Hinkle PM (September 2003). "Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation". Molecular Endocrinology. 17 (9): 1777–91. doi:10.1210/me.2003-0073. PMID 12805411.
• Igarashi-Migitaka J, Yamada S, Hara M, Sano T, Ozawa Y, Ohtani-Kaneko R, Hirata K (August 2003). "Gene expression study of thyrotropin releasing hormone (TRH) receptor using RT-PCR: relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas". Endocrine Journal. 50 (4): 459–67. doi:10.1507/endocrj.50.459. PMID 14599121.
• Cook LB, Hinkle PM (July 2004). "Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein". Endocrinology. 145 (7): 3095–100. doi:10.1210/en.2004-0304. PMID 15117874.

External links

• "Thyrotropin-Releasing Hormone Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• Receptors,+Thyrotropin-Releasing+Hormone at the US National Library of Medicine Medical Subject Headings (MeSH)