RGR-opsin is a member of the rhodopsin-like receptor subfamily of GPCR. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain.[3][4] RGR-opsin preferentially binds all-trans-retinal,[4] which is the dominant form in the dark adapted retina,upon light exposure it is isomerized to 11-cis-retinal.[5] Therefore, RGR-opsin presumably acts as a photoisomerase to convert all-trans-retinal to 11-cis-retinal, similar to retinochrome in invertebrates. 11-cis-retinal is isomerized back within rhodopsin and the iodopsins in the rods and cones of the retina. RGR-opsin is exclusively expressed in tissue close to the rods and cones, the retinal pigment epithelium (RPE) and Müller cells.[3] RGR-opsin may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). RGR-opsin comes in different isoforms produced by alternative splicing.[2]
↑Chen XN, Korenberg JR, Jiang M, Shen D, Fong HK (Jun 1996). "Localization of the human RGR opsin gene to chromosome 10q23". Human Genetics. 97 (6): 720–2. doi:10.1007/BF02346179. PMID8641686.
↑ 3.03.1Jiang M, Pandey S, Fong HK (Dec 1993). "An opsin homologue in the retina and pigment epithelium". Investigative Ophthalmology & Visual Science. 34 (13): 3669–78. PMID8258527.
↑ 4.04.1Shen D, Jiang M, Hao W, Tao L, Salazar M, Fong HK (Nov 1994). "A human opsin-related gene that encodes a retinaldehyde-binding protein". Biochemistry. 33 (44): 13117–25. doi:10.1021/bi00248a022. PMID7947717.
↑Hao, W; Fong, HK (5 March 1999). "The endogenous chromophore of retinal G protein-coupled receptor opsin from the pigment epithelium". The Journal of Biological Chemistry. 274 (10): 6085–90. doi:10.1074/jbc.274.10.6085. PMID10037690.
↑Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.
Further reading
Jiang M, Shen D, Tao L, Pandey S, Heller K, Fong HK (Apr 1995). "Alternative splicing in human retinal mRNA transcripts of an opsin-related protein". Experimental Eye Research. 60 (4): 401–6. doi:10.1016/S0014-4835(05)80096-X. PMID7789419.
Shen D, Jiang M, Hao W, Tao L, Salazar M, Fong HK (Nov 1994). "A human opsin-related gene that encodes a retinaldehyde-binding protein". Biochemistry. 33 (44): 13117–25. doi:10.1021/bi00248a022. PMID7947717.
Morimura H, Saindelle-Ribeaudeau F, Berson EL, Dryja TP (Dec 1999). "Mutations in RGR, encoding a light-sensitive opsin homologue, in patients with retinitis pigmentosa". Nature Genetics. 23 (4): 393–4. doi:10.1038/70496. PMID10581022.
Chen P, Lee TD, Fong HK (Jun 2001). "Interaction of 11-cis-retinol dehydrogenase with the chromophore of retinal g protein-coupled receptor opsin". The Journal of Biological Chemistry. 276 (24): 21098–104. doi:10.1074/jbc.M010441200. PMID11274198.
Yang M, Fong HK (Feb 2002). "Synthesis of the all-trans-retinal chromophore of retinal G protein-coupled receptor opsin in cultured pigment epithelial cells". The Journal of Biological Chemistry. 277 (5): 3318–24. doi:10.1074/jbc.M108946200. PMID11723126.
Lin MY, Kochounian H, Moore RE, Lee TD, Rao N, Fong HK (2007). "Deposition of exon-skipping splice isoform of human retinal G protein-coupled receptor from retinal pigment epithelium into Bruch's membrane". Molecular Vision. 13: 1203–14. PMID17679941.
