Prostaglandin D2 receptor
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| Prostaglandin D2 receptor (DP) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | PTGDR ; AS1; ASRT1; DP; MGC49004 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 736 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE PTGDR 215894 at tn.png | |||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Prostaglandin D2 receptor (DP), also known as PTGDR, is a receptor for prostaglandin D2, but also denotes the human gene encoding it.[1]
Mechanism
It is a G-protein-coupled receptor. The activity of it is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+.
Function
Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses.[1] It also causes vasodilation
See also
References
Further reading
- Boyce JA (2004). "The role of mast cells in asthma". Prostaglandins Leukot. Essent. Fatty Acids. 69 (2–3): 195–205. PMID 12895603.
- Chiba T, Kanda A, Ueki S; et al. (2007). "Possible novel receptor for PGD2 on human bronchial epithelial cells". Int. Arch. Allergy Immunol. 143 Suppl 1: 23–7. doi:10.1159/000101400. PMID 17541272.
- Senior J, Sangha R, Baxter GS; et al. (1992). "In vitro characterization of prostanoid FP-, DP-, IP- and TP-receptors on the non-pregnant human myometrium". Br. J. Pharmacol. 107 (1): 215–21. PMID 1422574.
- Boie Y, Sawyer N, Slipetz DM; et al. (1995). "Molecular cloning and characterization of the human prostanoid DP receptor". J. Biol. Chem. 270 (32): 18910–6. PMID 7642548.
- Ishikawa TO, Tamai Y, Rochelle JM; et al. (1997). "Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors". Genomics. 32 (2): 285–8. doi:10.1006/geno.1996.0118. PMID 8833158.
- Kobayashi T, Ushikubi F, Narumiya S (2000). "Amino acid residues conferring ligand binding properties of prostaglandin I and prostaglandin D receptors. Identification by site-directed mutagenesis". J. Biol. Chem. 275 (32): 24294–303. doi:10.1074/jbc.M002437200. PMID 10827082.
- Wright DH, Ford-Hutchinson AW, Chadee K, Metters KM (2001). "The human prostanoid DP receptor stimulates mucin secretion in LS174T cells". Br. J. Pharmacol. 131 (8): 1537–45. doi:10.1038/sj.bjp.0703688. PMID 11139429.
- Gervais FG, Cruz RP, Chateauneuf A; et al. (2002). "Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP". J. Allergy Clin. Immunol. 108 (6): 982–8. doi:10.1067/mai.2001.119919. PMID 11742277.
- Noguchi E, Shibasaki M, Kamioka M; et al. (2002). "New polymorphisms of haematopoietic prostaglandin D synthase and human prostanoid DP receptor genes". Clin. Exp. Allergy. 32 (1): 93–6. PMID 12002745.
- Hakonarson H, Bjornsdottir US, Halapi E; et al. (2002). "A major susceptibility gene for asthma maps to chromosome 14q24". Am. J. Hum. Genet. 71 (3): 483–91. PMID 12119603.
- Iwasaki M, Nagata K, Takano S; et al. (2002). "Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis". J. Invest. Dermatol. 119 (3): 609–16. doi:10.1046/j.1523-1747.2002.01862.x. PMID 12230502.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Moreland RB, Nehra A, Kim NN; et al. (2003). "Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscle". Int. J. Impot. Res. 14 (6): 446–52. doi:10.1038/sj.ijir.3900900. PMID 12494276.
- Faveeuw C, Gosset P, Bureau F; et al. (2003). "Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways". Eur. J. Immunol. 33 (4): 889–98. doi:10.1002/eji.200323330. PMID 12672054.
- Angeli V, Staumont D, Charbonnier AS; et al. (2004). "Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses". J. Immunol. 172 (6): 3822–9. PMID 15004188.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Oguma T, Palmer LJ, Birben E; et al. (2004). "Role of prostanoid DP receptor variants in susceptibility to asthma". N. Engl. J. Med. 351 (17): 1752–63. doi:10.1056/NEJMoa031785. PMID 15496624.
- Spik I, Brénuchon C, Angéli V; et al. (2005). "Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse". J. Immunol. 174 (6): 3703–8. PMID 15749909.
- Hirano Y, Shichijo M, Deguchi M; et al. (2007). "Synergistic effect of PGD2 via prostanoid DP receptor on TNF-alpha-induced production of MCP-1 and IL-8 in human monocytic THP-1 cells". Eur. J. Pharmacol. 560 (1): 81–8. doi:10.1016/j.ejphar.2007.01.003. PMID 17307163.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.