Arginine vasopressin receptor 2

Identifiers
Symbols	AVPR2 ; ADHR; DI1; DIR; DIR3; MGC126533; MGC138386; NDI; V2R
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20064
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Arginine vasopressin receptor 2 (AVPR2, also called V2 receptor) is a protein that acts as receptor for arginine vasopressin. AVPR2 belongs to the subfamily of G-protein coupled receptors. Its activity is mediated by the G_s type of G proteins, which stimulate adenylate cyclase.

AVPR2 is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, in fetal lung tissue and lung cancer, the last two being associated with alternative splicing. AVPR2 is also expressed outside the kidney and when stimulated a variety of clotting factors are released into the bloodstream.

In kidney AVPR2's primary property is to respond to arginine vasopressin by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of AVPR2 is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results.

Further reading

• Birnbaumer M (2001). "The V2 vasopressin receptor mutations and fluid homeostasis". Cardiovasc. Res. 51 (3): 409–15. PMID 11476731.
• Ishikawa SE (2002). "[Nephrogenic diabetes insipidus associated with mutations of vasopressin V2 receptors and aquaporin-2]". Nippon Rinsho. 60 (2): 350–5. PMID 11857925.
• Thibonnier M, Coles P, Thibonnier A, Shoham M (2002). "Molecular pharmacology and modeling of vasopressin receptors". Prog. Brain Res. 139: 179–96. PMID 12436935.CS1 maint: Multiple names: authors list (link)
• Bichet DG (2006). "Nephrogenic diabetes insipidus". Advances in chronic kidney disease. 13 (2): 96–104. doi:10.1053/j.ackd.2006.01.006. PMID 16580609.
• Robben JH, Knoers NV, Deen PM (2006). "Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus". Am. J. Physiol. Renal Physiol. 291 (2): F257–70. doi:10.1152/ajprenal.00491.2005. PMID 16825342.CS1 maint: Multiple names: authors list (link)
• Pan Y, Metzenberg A, Das S; et al. (1993). "Mutations in the V2 vasopressin receptor gene are associated with X-linked nephrogenic diabetes insipidus". Nat. Genet. 2 (2): 103–6. doi:10.1038/ng1092-103. PMID 1303257.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van den Ouweland AM, Dreesen JC, Verdijk M; et al. (1993). "Mutations in the vasopressin type 2 receptor gene (AVPR2) associated with nephrogenic diabetes insipidus". Nat. Genet. 2 (2): 99–102. doi:10.1038/ng1092-99. PMID 1303271.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van den Ouweland AM, Knoop MT, Knoers VV; et al. (1992). "Colocalization of the gene for nephrogenic diabetes insipidus (DIR) and the vasopressin type 2 receptor gene (AVPR2) in the Xq28 region". Genomics. 13 (4): 1350–2. PMID 1324225.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rosenthal W, Seibold A, Antaramian A; et al. (1992). "Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus". Nature. 359 (6392): 233–5. doi:10.1038/359233a0. PMID 1356229.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seibold A, Brabet P, Rosenthal W, Birnbaumer M (1992). "Structure and chromosomal localization of the human antidiuretic hormone receptor gene". Am. J. Hum. Genet. 51 (5): 1078–83. PMID 1415251.CS1 maint: Multiple names: authors list (link)
• Birnbaumer M, Seibold A, Gilbert S; et al. (1992). "Molecular cloning of the receptor for human antidiuretic hormone". Nature. 357 (6376): 333–5. doi:10.1038/357333a0. PMID 1534149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lolait SJ, O'Carroll AM, McBride OW; et al. (1992). "Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus". Nature. 357 (6376): 336–9. doi:10.1038/357336a0. PMID 1534150.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Knoers N, van der Heyden H, van Oost BA; et al. (1989). "Three-point linkage analysis using multiple DNA polymorphic markers in families with X-linked nephrogenic diabetes insipidus". Genomics. 4 (3): 434–7. PMID 2714800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsukaguchi H, Matsubara H, Taketani S; et al. (1995). "Binding-, intracellular transport-, and biosynthesis-defective mutants of vasopressin type 2 receptor in patients with X-linked nephrogenic diabetes insipidus". J. Clin. Invest. 96 (4): 2043–50. PMID 7560098.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Faà V, Ventruto ML, Loche S; et al. (1995). "Mutations in the vasopressin V2-receptor gene in three families of Italian descent with nephrogenic diabetes insipidus". Hum. Mol. Genet. 3 (9): 1685–6. PMID 7833930.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Birnbaumer M, Gilbert S, Rosenthal W (1995). "An extracellular congenital nephrogenic diabetes insipidus mutation of the vasopressin receptor reduces cell surface expression, affinity for ligand, and coupling to the Gs/adenylyl cyclase system". Mol. Endocrinol. 8 (7): 886–94. PMID 7984150.CS1 maint: Multiple names: authors list (link)
• Wenkert D, Merendino JJ, Shenker A; et al. (1995). "Novel mutations in the V2 vasopressin receptor gene of patients with X-linked nephrogenic diabetes insipidus". Hum. Mol. Genet. 3 (8): 1429–30. PMID 7987330.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oksche A, Dickson J, Schülein R; et al. (1995). "Two novel mutations in the vasopressin V2 receptor gene in patients with congenital nephrogenic diabetes insipidus". Biochem. Biophys. Res. Commun. 205 (1): 552–7. doi:10.1006/bbrc.1994.2700. PMID 7999078.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bichet DG, Birnbaumer M, Lonergan M; et al. (1994). "Nature and recurrence of AVPR2 mutations in X-linked nephrogenic diabetes insipidus". Am. J. Hum. Genet. 55 (2): 278–86. PMID 8037205.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yuasa H, Ito M, Oiso Y; et al. (1994). "Novel mutations in the V2 vasopressin receptor gene in two pedigrees with congenital nephrogenic diabetes insipidus". J. Clin. Endocrinol. Metab. 79 (2): 361–5. PMID 8045948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• IUPHAR GPCR Database - Arginine vasopressin receptor V₂