P87PIKAP

Jump to navigation Jump to search
Phosphoinositide-3-kinase adapter protein of 87 kDa
Identifiers
Symbolp87PIKAP
Alt. symbolsp84,PIK3R6
Entrez146850
HUGO27101
OMIM164730
RefSeqNM_005163
UniProtP31749
Other data
LocusChr. 17 p13.1

p87PIKAP is a regulatory subunit of the type IB Phosphoinositide 3-Kinase p110γ that is highly expressed in the heart and is present in dendritic cells, macrophages, and neutrophils.[1] It is also referred to as p84 and p87.[2] Some studies have found P87PIKAP to have a role in carcinogenesis.[3]

References

  1. ↑ Voigt P, Dorner MB, Schaefer M (2006). "Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B". The Journal of Biological Chemistry. 281 (15): 9977–86. doi:10.1074/jbc.M512502200. PMID 16476736.
  2. ↑ Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, et al. (2009). "Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma". Proceedings of the National Academy of Sciences of the United States of America. 106 (48): 20312–7. doi:10.1073/pnas.0905506106. PMC 2787109. PMID 19906996.
  3. ↑ Brazzatti, JA; et al. (2012). "Differential roles for the p101 and p84 regulatory subunits of PI3Kc in tumor growth and metastasis" (PDF). Oncogene. 31: 2350–2361. doi:10.1038/onc.2011.414.
File:Intro scheme3.jpg
The context of the function of p87.


Retrieved from "https://www.wikidoc.org/index.php?title=P87PIKAP&oldid=1529018"