Mitochondrial import inner membrane translocase subunit TIM16 also known as presequence translocated-associated motor subunit PAM16, mitochondria-associated granulocyte macrophage CSF-signaling molecule, or presequence translocated-associated motor subunit PAM16 is a protein that in humans is encoded by the PAM16 gene.[1][2][3]
The PAM16 gene is located on the p arm of chromosome 16 at position 13.3 and it spans 11,150 base pairs.[1] The PAM16 gene produces a 15.1 kDa protein composed of 137 amino acids.[4][5] The structure has been found to contain a 21-residue mitochondrial targeting leader sequence.[6]
↑Jubinsky PT, Messer A, Bender J, Morris RE, Ciraolo GM, Witte DP, Hawley RG, Short MK (December 2001). "Identification and characterization of Magmas, a novel mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction". Experimental Hematology. 29 (12): 1392–402. doi:10.1016/s0301-472x(01)00749-4. PMID11750097.
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Mick DU, Dennerlein S, Wiese H, Reinhold R, Pacheu-Grau D, Lorenzi I, Sasarman F, Weraarpachai W, Shoubridge EA, Warscheid B, Rehling P (December 2012). "MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation". Cell. 151 (7): 1528–41. doi:10.1016/j.cell.2012.11.053. PMID23260140.
Further reading
Tagliati F, Gentilin E, Buratto M, Molè D, degli Uberti EC, Zatelli MC (October 2010). "Magmas, a gene newly identified as overexpressed in human and mouse ACTH-secreting pituitary adenomas, protects pituitary cells from apoptotic stimuli". Endocrinology. 151 (10): 4635–42. doi:10.1210/en.2010-0441. PMID20719856.
Jubinsky PT, Short MK, Mutema G, Morris RE, Ciraolo GM, Li M (February 2005). "Magmas expression in neoplastic human prostate". Journal of Molecular Histology. 36 (1–2): 69–75. doi:10.1007/s10735-004-3840-8. PMID15704001.
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