PGC (gene)

Progastricsin (pepsinogen C)
File:PBB Protein PGC image.jpg PDB rendering based on 1avf.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1avf​, 1htr​
Identifiers
Symbols	PGC ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55669
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PGC 205261 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Progastricsin (pepsinogen C), also known as PGC, is a human gene.

Further reading

• Richter C, Tanaka T, Yada RY (1998). "Mechanism of activation of the gastric aspartic proteinases: pepsinogen, progastricsin and prochymosin". Biochem. J. 335 ( Pt 3): 481–90. PMID 9794784.CS1 maint: Multiple names: authors list (link)
• Sánchez LM, Freije JP, Merino AM; et al. (1992). "Isolation and characterization of a pepsin C zymogen produced by human breast tissues". J. Biol. Chem. 267 (34): 24725–31. PMID 1280267.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ichinose M, Miki K, Wong RN; et al. (1991). "Methylation and expression of human pepsinogen genes in normal tissues and their alteration in stomach cancer". Jpn. J. Cancer Res. 82 (6): 686–92. PMID 1906854.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Athauda SB, Tanji M, Kageyama T, Takahashi K (1990). "A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins". J. Biochem. 106 (5): 920–7. PMID 2515193.CS1 maint: Multiple names: authors list (link)
• Pals G, Azuma T, Mohandas TK; et al. (1989). "Human pepsinogen C (progastricsin) polymorphism: evidence for a single locus located at 6p21.1-pter". Genomics. 4 (2): 137–48. PMID 2567697.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taggart RT, Cass LG, Mohandas TK; et al. (1989). "Human pepsinogen C (progastricsin). Isolation of cDNA clones, localization to chromosome 6, and sequence homology with pepsinogen A.". J. Biol. Chem. 264 (1): 375–9. PMID 2909526.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Westerveld BD, Pals G, Bosma A; et al. (1987). "Gastric proteases in Barrett's esophagus". Gastroenterology. 93 (4): 774–8. PMID 3305135.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hayano T, Sogawa K, Ichihara Y; et al. (1988). "Primary structure of human pepsinogen C gene". J. Biol. Chem. 263 (3): 1382–5. PMID 3335549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Foltmann B, Jensen AL (1983). "Human progastricsin. Analysis of intermediates during activation into gastricsin and determination of the amino acid sequence of the propart". Eur. J. Biochem. 128 (1): 63–70. PMID 6816595.
• Moore SA, Sielecki AR, Chernaia MM; et al. (1995). "Crystal and molecular structures of human progastricsin at 1.62 A resolution". J. Mol. Biol. 247 (3): 466–85. doi:10.1006/jmbi.1994.0154. PMID 7714902.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Aabakken L, Axelsson CK, Szecsi PB (1993). "Pepsinogen A and C serum levels in relation to acute NSAID-associated mucosal lesions in healthy volunteers". Scand. J. Gastroenterol. 28 (6): 557–60. PMID 8322031.CS1 maint: Multiple names: authors list (link)
• Aoki T, Tomaki E, Morikawa J; et al. (1997). "Purification of pepsinogens from human urine and electrophoretic analysis by caseogram print". Biochem. Mol. Biol. Int. 39 (6): 1147–56. PMID 8876968.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Diamandis EP, Nadkarni S, Bhaumik B; et al. (1997). "Immunofluorometric assay of pepsinogen C and preliminary clinical applications". Clin. Chem. 43 (8 Pt 1): 1365–71. PMID 9267315.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Khan AR, Cherney MM, Tarasova NI, James MN (1998). "Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin". Nat. Struct. Biol. 4 (12): 1010–5. PMID 9406551.CS1 maint: Multiple names: authors list (link)
• Plebani M, Basso D, Navaglia F, DiMario F (1998). "Helicobacter pylori genotypes influence serum pepsinogen C levels". Helicobacter. 2 (4): 172–5. PMID 9421118.CS1 maint: Multiple names: authors list (link)
• Rojo JV, Merino AM, González LO, Vizoso F (2003). "Expression and clinical significance of pepsinogen C in epithelial ovarian carcinomas". Eur. J. Obstet. Gynecol. Reprod. Biol. 104 (1): 58–63. PMID 12128264.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)