PIP5K3

Phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III
Identifiers
Symbols	PIP5K3 ; CFD; KIAA0981; MGC40423; PIKFYVE; PIP5K
External IDs	Template:OMIM5 Template:MGI HomoloGene: 32115
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PIP5K3 213111 at tn.png
File:PBB GE PIP5K3 gnf1h04003 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III, also known as PIP5K3, is a human gene.

PIP5K3 belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol. Signaling by phosphorylated species of phosphatidylinositol regulates diverse cellular processes, including membrane trafficking and cytoskeletal reorganization (Shisheva et al., 1999).[supplied by OMIM]

Further reading

• Carpenter CL (2004). "Btk-dependent regulation of phosphoinositide synthesis". Biochem. Soc. Trans. 32 (Pt 2): 326–9. doi:10.1042/ . PMID 15046600.
• Shisheva A, Sbrissa D, Ikonomov O (1999). "Cloning, characterization, and expression of a novel Zn2+-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells". Mol. Cell. Biol. 19 (1): 623–34. PMID 9858586.CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Suyama M; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. PMID 10231032.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sbrissa D, Ikonomov OC, Shisheva A (2002). "Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localization". J. Biol. Chem. 277 (8): 6073–9. doi:10.1074/jbc.M110194200. PMID 11706043.CS1 maint: Multiple names: authors list (link)
• Sbrissa D, Ikonomov OC, Deeb R, Shisheva A (2003). "Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells". J. Biol. Chem. 277 (49): 47276–84. doi:10.1074/jbc.M207576200. PMID 12270933.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jiao X, Munier FL, Schorderet DF; et al. (2003). "Genetic linkage of Francois-Neetens fleck (mouchetée) corneal dystrophy to chromosome 2q35". Hum. Genet. 112 (5–6): 593–9. doi:10.1007/s00439-002-0905-1. PMID 12607114.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ikonomov OC, Sbrissa D, Mlak K; et al. (2004). "Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40". J. Biol. Chem. 278 (51): 50863–71. doi:10.1074/jbc.M307260200. PMID 14530284.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ikonomov OC, Sbrissa D, Foti M; et al. (2004). "PIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesis". Mol. Biol. Cell. 14 (11): 4581–91. doi:10.1091/mbc.E03-04-0222. PMID 14551253.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brill LM, Salomon AR, Ficarro SB; et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang SA, Carpenter CL, Abrams CS (2004). "Rho and Rho-kinase mediate thrombin-induced phosphatidylinositol 4-phosphate 5-kinase trafficking in platelets". J. Biol. Chem. 279 (40): 42331–6. doi:10.1074/jbc.M404335200. PMID 15277528.CS1 maint: Multiple names: authors list (link)
• Sbrissa D, Ikonomov OC, Strakova J; et al. (2005). "A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity". Mol. Cell. Biol. 24 (23): 10437–47. doi:10.1128/MCB.24.23.10437-10447.2004. PMID 15542851.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rush J, Moritz A, Lee KA; et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li S, Tiab L, Jiao X; et al. (2005). "Mutations in PIP5K3 are associated with François-Neetens mouchetée fleck corneal dystrophy". Am. J. Hum. Genet. 77 (1): 54–63. doi:10.1086/431346. PMID 15902656.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cabezas A, Pattni K, Stenmark H (2006). "Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1". Gene. 371 (1): 34–41. doi:10.1016/j.gene.2005.11.009. PMID 16448788.CS1 maint: Multiple names: authors list (link)
• Rutherford AC, Traer C, Wassmer T; et al. (2007). "The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport". J. Cell. Sci. 119 (Pt 19): 3944–57. doi:10.1242/jcs.03153. PMID 16954148.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Araki N, Hamasaki M, Egami Y, Hatae T (2007). "Effect of 3-methyladenine on the fusion process of macropinosomes in EGF-stimulated A431 cells". Cell Struct. Funct. 31 (2): 145–57. PMID 17146146.CS1 maint: Multiple names: authors list (link)