PLAGL1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Zinc finger protein PLAGL1 is a protein that in humans is encoded by the PLAGL1 gene.

Function

This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activity. This gene has been shown to exhibit antiproliferative activities and is a tumor suppressor gene candidate. Many transcript variants encoding two different isoforms have been found for this gene.

Interactions

PLAGL1 has been shown to interact with P53.

Further reading

• Vernon M (2005). "Fifty years of research on the intelligence of deaf and hard-of-hearing children: a review of literature and discussion of implications". J Deaf Stud Deaf Educ. 10 (3): 225–31. doi:10.1093/deafed/eni024. PMID 15888725.
• Abdollahi A, Roberts D, Godwin AK, Schultz DC, Sonoda G, Testa JR, Hamilton TC (1997). "Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors". Oncogene. 14 (16): 1973–9. doi:10.1038/sj.onc.1201034. PMID 9150364.
• Abdollahi A, Godwin AK, Miller PD, Getts LA, Schultz DC, Taguchi T, Testa JR, Hamilton TC (1997). "Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells". Cancer Res. 57 (10): 2029–34. PMID 9158001.
• Spengler D, Villalba M, Hoffmann A, Pantaloni C, Houssami S, Bockaert J, Journot L (1997). "Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain". EMBO J. 16 (10): 2814–25. doi:10.1093/emboj/16.10.2814. PMC 1169890. PMID 9184226.
• Abdollahi A, Bao R, Hamilton TC (1999). "LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein". Oncogene. 18 (47): 6477–87. doi:10.1038/sj.onc.1203067. PMID 10597250.
• Kamiya M, Judson H, Okazaki Y, Kusakabe M, Muramatsu M, Takada S, Takagi N, Arima T, Wake N, Kamimura K, Satomura K, Hermann R, Bonthron DT, Hayashizaki Y (2000). "The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes". Hum. Mol. Genet. 9 (3): 453–60. doi:10.1093/hmg/9.3.453. PMID 10655556.
• Bilanges B, Varrault A, Mazumdar A, Pantaloni C, Hoffmann A, Bockaert J, Spengler D, Journot L (2001). "Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities". Oncogene. 20 (10): 1246–53. doi:10.1038/sj.onc.1204237. PMID 11313869.
• Huang SM, Schönthal AH, Stallcup MR (2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene. 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. PMID 11360197.
• Mackay DJ, Coupe AM, Shield JP, Storr JN, Temple IK, Robinson DO (2002). "Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus". Hum. Genet. 110 (2): 139–44. doi:10.1007/s00439-001-0671-5. PMID 11935319.
• Abdollahi A, Pisarcik D, Roberts D, Weinstein J, Cairns P, Hamilton TC (2003). "LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer". J. Biol. Chem. 278 (8): 6041–9. doi:10.1074/jbc.M210361200. PMID 12473647.
• Hoffmann A, Ciani E, Boeckardt J, Holsboer F, Journot L, Spengler D (2003). "Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding". Mol. Cell. Biol. 23 (3): 988–1003. doi:10.1128/MCB.23.3.988-1003.2003. PMC 140694. PMID 12529403.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Ma D, Shield JP, Dean W, Leclerc I, Knauf C, Burcelin R, Rutter GA, Kelsey G (2004). "Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM". J. Clin. Invest. 114 (3): 339–48. doi:10.1172/JCI19876. PMC 484972. PMID 15286800.
• Cvetkovic D, Pisarcik D, Lee C, Hamilton TC, Abdollahi A (2004). "Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer". Gynecol. Oncol. 95 (3): 449–55. doi:10.1016/j.ygyno.2004.08.051. PMID 15581945.
• Mitchell J, Punthakee Z, Lo B, Bernard C, Chong K, Newman C, Cartier L, Desilets V, Cutz E, Hansen IL, Riley P, Polychronakos C (2004). "Neonatal diabetes, with hypoplastic pancreas, intestinal atresia and gall bladder hypoplasia: search for the aetiology of a new autosomal recessive syndrome". Diabetologia. 47 (12): 2160–7. doi:10.1007/s00125-004-1576-3. PMID 15592663.